Respiratory Infections Clinical Trial
Official title:
Estimating the Risk for and Severity of Respiratory Infections Attributable to CFTR Heterozygosity
A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays. An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19. The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.
Status | Recruiting |
Enrollment | 160 |
Est. completion date | July 2024 |
Est. primary completion date | July 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 100 Years |
Eligibility | CF Carrier Inclusion Criteria: - Previously tested and shown to be a CF carrier - English-speaking Control Group Inclusion Criteria: - Previously tested and shown to not be a CF carrier or CF patient - English-speaking Exclusion Criteria: - Currently sick with a respiratory infection - Prisoner Status - Unable to provide own written, informed consent |
Country | Name | City | State |
---|---|---|---|
United States | University of Iowa Hospitals and Clinics | Iowa City | Iowa |
Lead Sponsor | Collaborator |
---|---|
Philip Polgreen | National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Comparison of Chloride Transport Values | Comparison of chloride transport values in cystic fibrosis carrier group vs control group via t-test. | At baseline | |
Primary | Comparison of Bicarbonate Transport Values | Comparison of bicarbonate transport values in cystic fibrosis carrier group vs control group via t-test. | At baseline | |
Primary | Comparison of Airway Surface Liquid pH Values | Comparison of airway surface liquid pH values in cystic fibrosis carrier group vs control group via t-test. | At baseline | |
Primary | Comparison of Mucous Viscosity Values | Comparison of mucous viscosity values in cystic fibrosis carrier group vs control group via t-test. | At baseline | |
Primary | Comparison of Bacterial Killing Values | Comparison of bacterial killing values in cystic fibrosis carrier group vs control group via t-test. | At baseline | |
Secondary | Comparison of Fibroblast Growth Factor-19 Values | Comparison of fibroblast growth factor-19 values in cystic fibrosis carrier group vs control group via t-test. | At baseline |
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