Clinical Trials Logo

Clinical Trial Summary

IQOS ("I-Quit-Ordinary-Smoking,") is a type of "heat-not-burn" (HNB) tobacco product. There is evidence of a growing number of young people who try IQOS as a 'safe' alternative of cigarette. The effect of the acute exposure to IQOS smoke on pulmonary function of healthy non smokers has not been studied extensively.

Objectives: Evaluation of the acute effects of IQOS on pulmonary function,exhaled CO, O2 Saturation, arterial pressure and heart rate.

Methods: Healthy non smokers, underwent exhaled CO measurement, spirometry including flows, volumes and diffusion capacity, and measurement of their respiratory resistances at 5, 10 and 20 Hz (R5Hz, R10Hz and R20Hz) with the use of an impulse oscillometry system (IOS) before and after the use of an IQOS. Additionally heart rate and arterial blood pressure were also measured.


Clinical Trial Description

All participants underwent pulmonary function tests (PFT) (MasterScreen PFT, Jaeger, Wurzburg, Germany) and total respiratory resistances measurement with an impulse oscillometry system (IOS)( (Viasys Jaeger MasterScreen IOS system).From the basic pulmonary measurements (flows and dynamic lung volumes), Forced Expiratory Volume in 1 second (FEV1), Forced Vital Capacity (FVC), Tiffenau index (FEV1/FVC, FEV1%), Peak Expiratory Flow (PEF), Maximal Expiratory Flow (MEF) at 25%, 50%, and 75% of vital capacity, Functional Residual Capacity (FRC), Total Lung Capacity (TLC), Residual Volume (RV), Diffusion Capacity (DLCO) were measured. Each manoeuvre was repeated for at least three technically acceptable forced expiratory flow curves in order to attain the best results. Respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5, 10, and 20 Hz (R5Hz, R10Hz, and R20Hz, respectively), reactance at 5, 10, and 20 Hz and resonant frequency were assessed with IOS. Heart rate, saturation of O2 (oxymetry) and arterial blood pressure were also measured. Exhaled CO measurement (piCO Smokerlyzer,Bedfont Scientific Ltd, Kent, U.K.) was performed After smoking heated tobacco (IQOS): 5 minutes after smoking IQOS , they repeated again PFTs, IOS, exhaled CO heart rate, saturation of O2 (oximetry) and arterial blood pressure measurements. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03995329
Study type Interventional
Source Aristotle University Of Thessaloniki
Contact
Status Completed
Phase N/A
Start date June 19, 2019
Completion date July 10, 2019

See also
  Status Clinical Trial Phase
Completed NCT01143493 - The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Completed NCT04824573 - Effects of Manual Therapy and Inspiratory Muscle Training N/A
Recruiting NCT01881945 - Validation of Study in Respiratory Physiology and it Interactions N/A
Completed NCT03098784 - Nanoparticles Emitted by Aircraft Engines, Impact on Respiratory Function N/A
Not yet recruiting NCT04391361 - The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS Phase 2
Completed NCT06121960 - Evaluation of Respiratory Function During Self-induced Cognitive Trance N/A
Completed NCT03815799 - The Effect of Ultrasound-Guided Erector Spinae Block on Respiratory Function After Laparoscopic Cholecystectomy N/A
Active, not recruiting NCT01287000 - Gulf Long-Term Follow-Up Study
Active, not recruiting NCT04519255 - Study for Quantitative Analysis of the Recovered COVID-19 Patients by 18F-FDG-PET/CT
Not yet recruiting NCT05662072 - Motor Imagery and Action Observation in Respiratory Training N/A
Completed NCT03889990 - Acute Effects of a Heat-not-burn Tobacco Product on Pulmonary Function N/A
Completed NCT02074397 - Distant Extrafascial Injection vs Subfascial Injection for Interscalene Block: Acute Pain Outcomes and Rates of Complications N/A
Suspended NCT06198946 - External Diaphragm Pacing Therapy and Correlation Analysis of Trunk Balance and Respiratory Function in Stroke Patients N/A
Completed NCT03985917 - Singing Groups for Seniors: Well-Being, Cognitive Function and Health N/A
Not yet recruiting NCT02491762 - The Effect of Breast Reconstruction Surgery Using Tissue Expanders on Respiratory Functions N/A
Recruiting NCT06041126 - The Effect of Clinical Parameters on Muscle Oxygenation in Patients With COPD
Completed NCT01748643 - CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity Phase 4
Completed NCT06175286 - Effect of a Respiratory Training Program on Woodwind and Brass Players N/A