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Clinical Trial Summary

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.


Clinical Trial Description

Hyperpolarized 129Xe will be produced, by trained staff, using a polarizer housed at Cincinnati Children's Hospital Medical Center. Individual imaging sessions will be done on a single day and will involve administration of (maximum) 1 liter doses (less for children) for up to four MRI scans. Subject will inhale hyperpolarized xenon gas and hold breath for up to 16 seconds during the MRI scans. In addition to 129 Xe MRI, a series of anatomical conventional proton MR images may also be collected. Follow up phone calls will be done one day and 30 days from the MRI date. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02272049
Study type Interventional
Source Children's Hospital Medical Center, Cincinnati
Contact Carrie Stevens, BS
Phone 513-636-9973
Email Carrie.Stevens@cchmc.org
Status Recruiting
Phase Phase 1/Phase 2
Start date December 2014
Completion date August 2027

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