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Respiratory Depression clinical trials

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NCT ID: NCT02903173 Completed - Pregnancy Clinical Trials

An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)

Start date: February 2015
Phase:
Study type: Observational

The purpose of this study is to evaluate the breathing patterns of women who undergo cesarean delivery with spinal or epidural morphine for post-operative pain control in the first day after surgery. Some women who undergo cesarean delivery may be at risk for respiratory complications related to opiate administration for post-operative pain. The primary aim of this study is to evaluate post-operative minute ventilation in women who undergo cesarean delivery using a novel method of non-invasive minute ventilation monitoring, and to see if there are predictive risk factors that may predispose women to post-operative hypoventilation.

NCT ID: NCT02885948 Completed - Clinical trials for Respiratory Depression

The Use of Low Dose Prophylactic Naloxone Infusion to Prevent Respiratory Depression With Intrathecal Morphine.

NAPRESSIM
Start date: April 2016
Phase: Phase 4
Study type: Interventional

This is an investigator led, randomised, double blind, placebo controlled, double arm comparator study.

NCT ID: NCT02811302 Completed - Clinical trials for Respiratory Depression

PRediction of Opioid-induced Respiratory Depression In Patients Monitored by capnoGraphY

PRODIGY
Start date: April 7, 2017
Phase: N/A
Study type: Interventional

PRODIGY is a prospective, multi-center, post-market, international cohort study. The primary objective of this study is to derive a score to identify subjects at risk to have respiratory depression (RD) episodes in patients undergoing opioid therapy in the hospital ward and monitored by capnography. The score will be derived by using subjects within the derivation cohort and internally validated using subjects within the validation cohort. The primary endpoint used to derive the score will be the occurrence of RD episodes derived by Capnostream 20p device memory data combined with clinical data and validated by an independent Clinical Endpoint Committee (CEC) during the study course.

NCT ID: NCT02707003 Completed - Clinical trials for Respiratory Depression

Clinical Utility of Capnography in the PACU( Post-anaesthesia Care Unit)

Start date: February 2016
Phase:
Study type: Observational

Multi-center observational trial with study device blinded in order to assess in parallel standard monitoring and intervention practices related to management of respiratory compromise in the post-anaesthesia care unit (PACU)

NCT ID: NCT02481570 Completed - Postoperative Pain Clinical Trials

Anesthetic Optimization in Scoliosis Surgery

AIS
Start date: November 2015
Phase: N/A
Study type: Interventional

The standard anesthetic care plan for people having adolescent idiopathic scoliosis surgery will be accompanied by a pharmacokinetic simulation of the administered drugs to suggest opportunities to adjust drug doses to achieve tolerable pain control after surgery, avoid respiratory depression and allow patients to respond quickly either during intraoperative testing or at the conclusion of surgery.

NCT ID: NCT02473354 Completed - Clinical trials for Respiratory Depression

Predictors of Opioid-Induced Respiratory Depression (OIRD)

(OIRD)
Start date: April 2015
Phase: Phase 1
Study type: Interventional

Purpose of the Study: (1) To classify an individual subject's ventilatory response in terms of respiratory depression to a bolus of remifentanil under normoxic and hyperoxic conditions. (2) Measurement of specific respiratory parameters to predict the opioid-induced respiratory depression (OIRD) response.

NCT ID: NCT02417038 Completed - Clinical trials for Respiratory Depression

Postoperative Respiratory Monitoring After Neuraxial Opioid Administration for Cesarean Delivery

Start date: April 2015
Phase: N/A
Study type: Observational

Respiratory depression occurs in labor and delivery; noticeably when neuraxial opioids are given.Pathophysiological respiratory depression -failure to respond to hypercapnia or hypoxia - is challenging to measure clinically.American Society of Anesthesiologist guidelines recommend suitable respiratory monitoring for 24 hours post cesarean delivery (CD). Use of capnograph will enable us to assess breath-by-breathe respiration in a population receiving neuraxial opioids - potentially at risk for respiratory depression. Our aim is to assess our ability to capture maternal postpartum respiratory parameters in a cohort following opioid neuraxial administration for CD.

NCT ID: NCT02133586 Completed - Clinical trials for Respiratory Depression

Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers.

ENDZONE
Start date: January 2014
Phase: N/A
Study type: Interventional

The U.S. Environmental Protection Agency has traditionally examined the effects of single pollutant exposure on human health outcomes; however, to provide a better assessment of pollutant exposure-associated effect on human health the Agency is moving toward a multi-pollutant approach. Ozone (O3) and nitrogen dioxide (NO2) are national ambient air quality standards (NAAQS) criteria pollutants that are major constituents of ambient air pollution. This study will address the Agency's goals by investigating the cardiopulmonary health effects of sequential exposure to O3 and NO2 in healthy adult human volunteers. The findings of this study will provide data that will inform risk assessment models for O3 and NO2 exposures. Additionally, the findings will provide insight into how the human health effects of multi-pollutant exposures differ from those of single pollutant exposures.

NCT ID: NCT01969227 Completed - Clinical trials for Mechanical Ventilation

The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

Start date: January 2014
Phase: N/A
Study type: Interventional

Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodilation. At subanesthetic plasma concentration, ketamine reduces both opioid and propofol requirements. The purpose of this pharmaco-physiological interaction trial is to evaluate the effects of ketamine on breathing and electroencephalography in mechanically ventilated patients.

NCT ID: NCT01874834 Completed - Blood Pressure Clinical Trials

Cardiopulmonary Responses to Exposure to Ozone and Diesel Exhaust

DEPOZ
Start date: August 2010
Phase: N/A
Study type: Interventional

The US EPA Clean Air Multiyear research program is moving toward a multi-pollutant approach to the assessment of air pollution in response to recommendations by the NRC 2004 and the BOSC in 2005. Such an approach better reflects the complexity of real-world air pollution problems and parallels evolving scientific and regulatory considerations. Ozone (O3) and diesel exhaust (DE) generally are major and important components of ambient air pollution. This proposed study will address the agency's goals by investigating the cardiopulmonary health effects in healthy human subjects co-exposed to O3 and DE. The findings derived from these exposures will provide NCEA findings for risk assessments of O3 and DE, as well as the Office of Air and Radiation (includes OTAQ and OAQPS) with information relevant to possible modulation of PM-induced health effects and responses by a gaseous co-pollutant for potential standard setting. Additionally the findings will address the fundamental driving principle of the Clean Air Research strategy related to reduction of health due to air pollutant exposures.