Clinical Trials Logo
  1. Home
  2. Respiratory Complication
  3. NCT06443515

Respiratory Trends During Blood Transfusions in Newborns. — ARTE  

Respiratory Complication Clinical Trial

Official title:
Evaluation of Respiratory Trends During Blood Transfusions in Newborns.

Clinical Trial Summary

The prevalence of transfusion reactions is between 1 and 11% of transfusions. Most reactions are mild and do not pose a life-threatening risk to the patient. More serious problems may be the only manifestations that lead to suspicion of a transfusion reaction. Most noninfectious transfusion reactions are immune-mediated. Two main types of reactions can be distinguished: TACO (transfusion associated cardiac overload, which is a cardiogenic pulmonary edema) and TRALI (transfusion related acute lung injury, non-cardiogenic pulmonary edema). Although TRALI are diagnoses of exclusion, the presence of noncardiogenic pulmonary edema and respiratory problems in the vicinity of blood product transfusions should raise suspicion. Other signs of TRALI are hypotension and tachycardia, while in TACO arterial hypertension with positive water balance can be observed. According to previous reports, the prevalence of transfusion reactions in the neonatal population is approximately 8%. Factors associated with these reactions are low birth weight and low gestational age. However, diagnostic criteria of respiratory transfusion reactions are not uniform across studies, and often the generic terms "acute lung injury" have been used. Therefore, the primary objective of this study is to evaluate the respiratory trend during blood transfusions; secondary objectives are the study of risk factors for the development of respiratory worsening and the possible association with complications.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06443515
Study type Interventional
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Stefano Nobile, MD, PhD, MSc
Phone +39 06 30151
Email stefano.nobile@policlinicogemelli.it
Status Not yet recruiting
Phase N/A
Start date June 7, 2024
Completion date January 15, 2026
View Details
See also
  Status Clinical Trial Phase
Completed NCT03946137 - Chest Therapy and Postural Education in Children With Cerebral Palsy N/A
Completed NCT06089226 - Parameters Related to Physical Activity Level in SCI
Completed NCT03931902 - The Comparison of Laryngeal Mask Airway and Endotracheal Tube in General Anesthesia for Premature Neonates N/A
Completed NCT03105739 - Timing of Withdrawal of the Laryngeal Mask Airway (LMA) in Children N/A
Recruiting NCT04100512 - Oscillating Positive Expiratory Pressure (OPEP) Therapy in Trauma Patients With Multiple Rib Fractures N/A
Enrolling by invitation NCT06360666 - Clinical Outcomes in Adult Patients Undergoing Laparoscopic Surgery Under Neuraxial Anesthesia
Recruiting NCT06149494 - RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection Phase 2
Completed NCT03056885 - Inflammatory Local Response During OLV: Protective vs Conventional Ventilation Strategy N/A
Recruiting NCT05136781 - DEXAMETHASONE for Non-urgent Thoracic Surgery
Terminated NCT03665259 - Lower Inspiratory Oxygen Fraction for Preoxygenation N/A
Not yet recruiting NCT03255356 - Ventilation in Cardiac Surgery N/A
Terminated NCT03571646 - LIFEGUARD Study - Continuous Respiratory Monitoring on the General Ward N/A
Not yet recruiting NCT05363098 - The Cerebral-Respiratory Interaction During Spontaneous Breathing Ventilation in Neurosurgical Patients (CeRes-SB)
Recruiting NCT03969147 - Investigation of a Novel Oropharyngeal Airway: The ManMaxAirway N/A
Not yet recruiting NCT06412081 - Lung Ultrasound for Physiotherapy in Hospitalized Patients With Respiratory Complications
Completed NCT03218215 - Monitoring Mechanical Assisted Cough N/A
Completed NCT03102619 - Wireless Assessment of Respiratory and Circulatory Distress; A Pilot Study N/A
Recruiting NCT05804175 - Advanced Prediction of Respiratory Depression Episode With the Linshom Continuous Predictive Respiratory Sensor
Recruiting NCT06301126 - Virtual Reality on Pulmonary Function After Upper Abdominal Surgeries N/A
Recruiting NCT05354466 - Perioperative Respiratory Adverse events_sugammadex N/A