Clinical Trials Logo
  1. Home
  2. Respiratory Complication
  3. NCT05856136
  4. Details
NCT05856136 Clinical Trial

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Respiratory Complication Clinical Trial

Official title:
Investigation of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle to Generate Higher Force Behaviors

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05856136
Other study ID # 20-007084
Secondary ID R21DA055848
Status Recruiting
Phase Phase 4
First received
Last updated
Start date June 19, 2023
Est. completion date April 2024

Study information
Verified date August 2023
Source Mayo Clinic
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date April 2024
Est. primary completion date April 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system). Exclusion Criteria: - Patients who refuse research participation. - Patients who are pregnant. - Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Fentanyl Injection
Three different fentanyl doses (used for sedation) will be evaluated on their effects on shear wave elastography (SWE) and breathing

Locations
Country Name City State
United States Mayo Clinic Minnesota Rochester Minnesota

Sponsors (2)
Lead Sponsor Collaborator
Mayo Clinic National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in shear wave speed Measured by the ultrasound elastography of the diaphragm muscle reported in m/sec Baseline, 1 hour
See also
  Status Clinical Trial Phase
Completed NCT03946137 - Chest Therapy and Postural Education in Children With Cerebral Palsy N/A
Completed NCT06089226 - Parameters Related to Physical Activity Level in SCI
Completed NCT03931902 - The Comparison of Laryngeal Mask Airway and Endotracheal Tube in General Anesthesia for Premature Neonates N/A
Completed NCT03105739 - Timing of Withdrawal of the Laryngeal Mask Airway (LMA) in Children N/A
Recruiting NCT04100512 - Oscillating Positive Expiratory Pressure (OPEP) Therapy in Trauma Patients With Multiple Rib Fractures N/A
Enrolling by invitation NCT06360666 - Clinical Outcomes in Adult Patients Undergoing Laparoscopic Surgery Under Neuraxial Anesthesia
Recruiting NCT06149494 - RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection Phase 2
Completed NCT03056885 - Inflammatory Local Response During OLV: Protective vs Conventional Ventilation Strategy N/A
Recruiting NCT05136781 - DEXAMETHASONE for Non-urgent Thoracic Surgery
Terminated NCT03665259 - Lower Inspiratory Oxygen Fraction for Preoxygenation N/A
Not yet recruiting NCT03255356 - Ventilation in Cardiac Surgery N/A
Terminated NCT03571646 - LIFEGUARD Study - Continuous Respiratory Monitoring on the General Ward N/A
Not yet recruiting NCT05363098 - The Cerebral-Respiratory Interaction During Spontaneous Breathing Ventilation in Neurosurgical Patients (CeRes-SB)
Recruiting NCT03969147 - Investigation of a Novel Oropharyngeal Airway: The ManMaxAirway N/A
Recruiting NCT06412081 - Lung Ultrasound for Physiotherapy in Hospitalized Patients With Respiratory Complications
Completed NCT03218215 - Monitoring Mechanical Assisted Cough N/A
Completed NCT03102619 - Wireless Assessment of Respiratory and Circulatory Distress; A Pilot Study N/A
Recruiting NCT05804175 - Advanced Prediction of Respiratory Depression Episode With the Linshom Continuous Predictive Respiratory Sensor
Recruiting NCT06301126 - Virtual Reality on Pulmonary Function After Upper Abdominal Surgeries N/A
Not yet recruiting NCT06443515 - Respiratory Trends During Blood Transfusions in Newborns. N/A

External Links