Aortic Cross Clamping Time, and Postoperative Respiratory Function

Respiratory Complication Clinical Trial

Official title:

Implication of Aortic Cross Clamping Time Upon Postoperative Respiratory Function in Adult Patients Undergoing Open Heart Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03072784
• Other study ID #: IRB00009915
• Status: Completed
• Phase: N/A
• First received: February 15, 2017
• Last updated: March 7, 2017
• Start date: February 1, 2015
• Est. completion date: August 25, 2016

Study information

• Verified date: March 2017
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.

Description:

Cardiac surgery usually is done under cardiopulmonary bypass. As the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. Of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. Follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 53
• Est. completion date: August 25, 2016
• Est. primary completion date: April 20, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• adult patients

• elective open heart surgery

Exclusion Criteria:

• Patients with myocardial ischemia or previous infarction

• low ejection fraction <30%

• history of AF

• implanted pacemaker

• uncontrolled hypertension

• renal impairment (creatinine >1.8 mg/dl)

• hepatic dysfunction

• insulin dependent diabetes

• chronic pulmonary disease

Related Conditions & MeSH terms

• Bypass Complication
• Respiratory Complication

Intervention

Procedure:
• aortic cross clamping
duration of cross clamping, less than 90 minutes, or more than 90 minutes

Locations

Country	Name	City	State
Egypt	Emad Zarief Kamel Said	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	quality of oxygenation	PaO2 mmHg	48 hours postoperative
Secondary	time to extubation	time to extubate in minutes	24 hours postoperative
Secondary	ventilation	respiratory rate (breath/minute)	48 hours postoperative
Secondary	carbon dioxide	PaCO2 mmhg	48 hours