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Respiration; Sleep Disorder clinical trials

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NCT ID: NCT03734341 Completed - Clinical trials for Sleep Apnea, Obstructive

Comparison of Two Telemonitoring Auto-titrating Modalities in OSA Patients

Start date: April 1, 2018
Phase: N/A
Study type: Interventional

This study compares the titration pressures achieved through two auto-titrating modalities, a new incremental fixed pressure mode versus routine auto-adjusting pressure mode, in CPAP-naïve obstructive sleep apnea patients. The aim of the study is to verify that this new modality achieves a lower titration pressure.

NCT ID: NCT03335904 Completed - Hypoxia Clinical Trials

AT1R Blockade and Periodic Breathing During Sleep in Hypoxia

Start date: January 1, 2018
Phase: Phase 4
Study type: Interventional

Sleep disordered breathing (SDB) is characterized by regular periods of no breathing (apnea) or low levels of breathing (hypopnea) and leads to repeated periods of low oxygenation, termed intermittent hypoxia that causes fluctuations in blood oxygen levels. This leads to increased peripheral chemoreflex sensitivity that is thought to occur through the stimulation of angiotensin-II, type-I receptors (AT1R) that are expressed primarily on glomus cells within the peripheral chemoreflex and ultimately results in long lasting hypertension. The goal of this study is to determine if AT1R receptor blockade can prevent the increase in chemoreflex sensitivity following one night of hypoxia and improve the severity of SDB.