Respiration Disorders Clinical Trial
Official title:
The Austrian LEAD (Lung hEart sociAl boDy) Study
The Austrian LEAD study is the first investigation initiated in Austria that aims to investigate the prevalence and the natural history of COPD in a reference population of Austria.
Chronic obstructive pulmonary disease (COPD) is one of the most important causes of
morbidity and mortality worldwide and has a tremendous impact on the individual patient, the
healthcare system, and the general public.
Contrary to other chronic diseases, the natural history of COPD, commonly described with the
natural decline of lung function, has not been investigated sufficiently and the presence of
various phenotypes is still under intensive investigation.
The investigators aim to study the natural course of lung function and the development of
COPD in a longitudinal, observational, population based cohort in Austria.
Study population (male and female, age 6 - 80 years) will be randomly recruited via the
national inhabitants register in both Vienna (urban cohort) and Lower Austria (rural
cohort).
Health examinations will include lung function testing, cardiovascular examinations, body
composition and metabolic testing as well as socioeconomic counseling. Furthermore, the
initiation of a bio bank will provide serological testing on biomarker and epigenetic
analysis.
In particular, the investigators intend to assess a) the age-related natural decline in lung
function in the general population, b) the prevalence of COPD and the development of major
respiratory symptoms in this disease, c) the prevalence of the most important COPD
comorbidities (cardiovascular, metabolic and cognitive dysfunction) and d) the association
between lung health and social status, individual long term exposure to air pollution and
other toxic inhalants.
This health examination will be the first investigation in Austria providing information
about the most prevalent respiratory disease and it`s comorbidities in a longitudinal
approach.
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Observational Model: Cohort, Time Perspective: Prospective
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