Resistant Starch Type-3, Glucose Metabolism and Appetite

Resistant Starch Clinical Trial

Official title:

Impact of Resistant Starch Type-3 on Glucose Metabolism and Appetite in Healthy Adult Males

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05108142
• Other study ID #: 19/01008
• Status: Completed
• Phase: N/A
• Start date: November 1, 2019
• Est. completion date: March 15, 2020

Study information

• Verified date: November 2021
• Source: King Saud University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Resistant starch (RS) is considered to have many of the same health benefits as dietary fiber. The aim of this study was to examine the effects of RS3 on postprandial glycemic and insulinemic responses and appetite. Healthy males (aged 18-35 years) participated in this study. Subjects were provided meals in the laboratory after overnight fasting on two separate occasions, at least 1 week apart. On each laboratory visit, subjects were given either a control meal (COM) or an RS3 meal (RSM). Both meals during the two visits consisted of vegetarian pasta and were matched for energy intake, composition, ingredients, and amount, but were prepared in different ways. The COM was hot, freshly cooked pasta, while the RSM was re-heated pasta that had been cooked the previous day and chilled overnight. Blood samples and subjective appetite ratings were collected at fasting and for a period of 3 h after meal consumption (i.e., 15-min intervals for glucose and 30-min intervals for insulin, ghrelin, and subjective appetite).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: March 15, 2020
• Est. primary completion date: March 15, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy males
• Aged between 18 and 40 years
• Normal weight (BMI 18.5-24.9 kg/m2)
• No history of serious disease or currently taking any medications
• Not dieting or seeking to lose weight.

Exclusion Criteria:

• Smokers
• Allergy to gluten-containing products, lactose intolerance, or dairy allergy
• Particular dislike to any of the foods provided during the study.

Related Conditions & MeSH terms

• Resistant Starch

Intervention

Other:
• Dietary intervention
fresh, hot pasta and re-heated pasta

Locations

Country	Name	City	State
Saudi Arabia	Maha Alhussain	Riyadh

Sponsors (1)

Lead Sponsor	Collaborator
King Saud University

Country where clinical trial is conducted

Saudi Arabia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in fasting and postprandial blood glucose concentrations (n=8)	Fasting and postprandial blood glucose assessed with the use of a portable monitor (Accu-Chek) during laboratory visits (before and 3 hours following the meal consumption in the two visits).	3 hours
Secondary	Changes in of fasting and postprandial serum insulin concentrations (n=8)	Fasting and postprandial serum insulin assessed using a commercial kit during laboratory visits (before and 3 hours following the meal consumption in the two visits)	3 hours
Secondary	Changes in subjective appetite ratings (Visual Analogue Scale) (n=8)	Subjective appetite ratings were assessed during laboratory visits (before and 3 hours following the meal consumption in the two visits) with the use of paper-based visual analog scales with words anchored at each end of a 100-mm horizontal line that expressed the most-positive rating and the most-negative rating for a question. The questions were in the form of "How (rating) do you feel?" (with ratings of hungry, satisfied, and full), "How much of a desire to eat?" and "How much do you think you can eat?"	3 hours
Secondary	Changes in fasting and postprandial plasma ghrelin concentrations (n=8)	Fasting and postprandial ghrelin assessed using a commercial kit during laboratory visits (before and 3 hours following the meal consumption in the two visits)	3 hours