Adaptive Response of Brain Towards Resistance Training in Healthy Individuals

Resistance Training Clinical Trial

Official title:

Adaptive Response of Brain Towards Resistance Training in Healthy Individuals

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06413199
• Other study ID #: PSRDHospital
• Status: Recruiting
• Phase: N/A
• Start date: August 18, 2023
• Est. completion date: December 31, 2024

Study information

• Verified date: May 2024
• Source: Pakistan Society for Rehabilitation of Differently Abled Hospital
• Contact: Muhammad Faheem Afzal, PhD*
• Phone: 00923336966697
• Email: faheem78601[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The novelty of this study is to identify the mechanism of nervous system by applying resistance training intervention in healthy individuals.

Description:

Resistance training is a form of exercise that is popular particularly for its role in improving athletic performance by increasing muscular strength, power and speed, hypertrophy, local muscular endurance, motor performance, balance and coordination. The objective of the study is to find out the effects of resistance training on Central and Peripheral Nervous System in healthy individuals. A total of 100 participants will be included in the study including both male and female. The study will be divided into two main groups. Experimental group will perform 8-12 Reps with 1.5 sec concentric and 1.5 sec eccentric contraction of bench press with 90 sec of rest between sets with 2 sets per week for 2 months.

1RM of control group will be calculated through the same method and the training protocol for the Control group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 31, 2024
• Est. primary completion date: December 29, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Body Mass Index should be 18.5-24.9 kg/m2.

• Participants were untrained and had not engaged in resistance exercise within 6 months prior to beginning the study.

Exclusion Criteria:

• Participants with any kind of Gastrointestinal Tract disturbance will be excluded from the study.

• Participants with any kind of Musculoskeletal injury will be excluded from the study.

• Participant with any kind of Neurological disturbance will be excluded from the study.

• Participants who use tobacco products within the previous 6 months.

• Participants who take any type of medication within the previous 6 months.

Related Conditions & MeSH terms

• Resistance Training

Intervention

Other:
• Hyper Training
Experimental group will perform 2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 Reps with 90 seconds rest between sets. 1.5 second concentric and 1.5 second eccentric contraction of bench press, The elbows had to be fully locked out to be counted as a repetition.
• 1 Repetition maximum training group
2 training session per week for 8 weeks, 1 set of 10 unloaded repetitions in arms as a warm-up, 1 Repetition maximum training group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts, the load was progressively increased each attempt to try to reach or exceed their previous 1 repetition maximum.

Locations

Country	Name	City	State
Pakistan	PSRD Hospital	Lahore	Punjab

Sponsors (2)

Lead Sponsor	Collaborator
Pakistan Society for Rehabilitation of Differently Abled Hospital	University of Karachi

Country where clinical trial is conducted

Pakistan, 

References & Publications (22)

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Griffin L, Cafarelli E. Transcranial magnetic stimulation during resistance training of the tibialis anterior muscle. J Electromyogr Kinesiol. 2007 Aug;17(4):446-52. doi: 10.1016/j.jelekin.2006.05.001. Epub 2006 Aug 7. — View Citation

Hakkinen K, Alen M, Komi PV. Changes in isometric force- and relaxation-time, electromyographic and muscle fibre characteristics of human skeletal muscle during strength training and detraining. Acta Physiol Scand. 1985 Dec;125(4):573-85. doi: 10.1111/j.1748-1716.1985.tb07760.x. — View Citation

Jessee MB, Buckner SL, Mouser JG, Mattocks KT, Dankel SJ, Abe T, Bell ZW, Bentley JP, Loenneke JP. Muscle Adaptations to High-Load Training and Very Low-Load Training With and Without Blood Flow Restriction. Front Physiol. 2018 Oct 16;9:1448. doi: 10.3389/fphys.2018.01448. eCollection 2018. — View Citation

Kacin A, Strazar K. Frequent low-load ischemic resistance exercise to failure enhances muscle oxygen delivery and endurance capacity. Scand J Med Sci Sports. 2011 Dec;21(6):e231-41. doi: 10.1111/j.1600-0838.2010.01260.x. Epub 2011 Mar 8. — View Citation

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Mattocks KT, Buckner SL, Jessee MB, Dankel SJ, Mouser JG, Loenneke JP. Practicing the Test Produces Strength Equivalent to Higher Volume Training. Med Sci Sports Exerc. 2017 Sep;49(9):1945-1954. doi: 10.1249/MSS.0000000000001300. — View Citation

Mitchell CJ, Churchward-Venne TA, West DW, Burd NA, Breen L, Baker SK, Phillips SM. Resistance exercise load does not determine training-mediated hypertrophic gains in young men. J Appl Physiol (1985). 2012 Jul;113(1):71-7. doi: 10.1152/japplphysiol.00307.2012. Epub 2012 Apr 19. — View Citation

Ribeiro AS, Tomeleri CM, Souza MF, Pina FL, Schoenfeld BJ, Nascimento MA, Venturini D, Barbosa DS, Cyrino ES. Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience. Age (Dordr). 2015 Dec;37(6):109. doi: 10.1007/s11357-015-9849-y. Epub 2015 Oct 26. — View Citation

Taber CB, Vigotsky A, Nuckols G, Haun CT. Exercise-Induced Myofibrillar Hypertrophy is a Contributory Cause of Gains in Muscle Strength. Sports Med. 2019 Jul;49(7):993-997. doi: 10.1007/s40279-019-01107-8. No abstract available. — View Citation

Westerblad H, Allen DG. Changes of myoplasmic calcium concentration during fatigue in single mouse muscle fibers. J Gen Physiol. 1991 Sep;98(3):615-35. doi: 10.1085/jgp.98.3.615. — View Citation

* Note: There are 22 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	NCS (Motor Nerve Conduction Study)	To determine how fast or slow the nerves are conducting an electrical current using F wave	• 0 week • 8th week
Primary	EEG (Electroencephalography)	To measure the electrical activity of the brain using alpha and beta waves	• 0 week • 8th week
Primary	Dynamometer	To measure the strength after resistance training	• 0 week • 4th week • 8th week
Primary	Estimation of Albumin & Globulin ratio	To measure the total amount of protein in blood and effects of resistance training	• 0 week • 8th week