Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions

Resistance Training Clinical Trial

Official title:

Acute and Chronic Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions on Muscle Strength, Thickness, Catecholamine, and Inflammatory Responses in Physically Active Adults

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06171841
• Other study ID #: SKN/SP/569582/2023
• Status: Active, not recruiting
• Phase: N/A
• Start date: November 20, 2023
• Est. completion date: July 1, 2024

Study information

• Verified date: June 2024
• Source: The Jerzy Kukuczka Academy of Physical Education in Katowice
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions. This is likely due to heightened physiological responses. While sports science research indicates a substantial impact of hypoxic conditions on immediate increases in metabolic stress and augmented hormonal responses, recent findings suggest that the role of their influence on skeletal muscle adaptations post-resistance training under hypoxic conditions remains unknown. Additionally, there is a lack of reports on whether the type of hypoxia applied via blood flow restriction or chamber differentiates the increase in secretion of these catecholamines in both immediate and long-term aspects.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 60
• Est. completion date: July 1, 2024
• Est. primary completion date: June 20, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Regularly physically active (at least 30 mins of structured exercise 3 times per week),

• Sea-level natives,

• Experienced in resistance training (at least one year of experience in regular resistance exercise)

Exclusion Criteria:

• presence of any medical risk factors to exercise and/or exposure to altitude

• presence of any medical condition that would make the protocol unreasonably hazardous for the participant

• smokers

Related Conditions & MeSH terms

• Altitude Sickness
• Blood Flow Restriction
• Hypoxia
• Hypoxia, Altitude
• Resistance Training

Intervention

Other:
• low-intensity resistance training
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions performed twice a week for 6 weeks.
• high-intensity resistance training
4 sets of 10 repetitions of leg press exercise at 70-80% one-repetition maximum (weeks 1-3: 70%, weeks 4-6: 80%) in normoxic conditions performed twice a week for 6 weeks.
• low-intensity resistance training combined with blood flow restriction
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.
• low-intensity resistance training in hypoxia condition
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in hypoxia conditions (3500 meters above sea) performed twice a week for 6 weeks.
• low-intensity resistance training combined with blood flow restriction in hypoxia condition
4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normobaric hypoxia conditions (3500 meters above sea) with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.

Locations

Country	Name	City	State
Poland	The Jerzy Kukuczka Academy of Physical Education	Katowice	Slask

Sponsors (1)

Lead Sponsor	Collaborator
The Jerzy Kukuczka Academy of Physical Education in Katowice

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Total Body Mass	Dual-energy X-ray absorptiometry will be used to quantify total body mass (kg).	within 5 days from the start and end of training
Other	Percentage Body Fat	Dual-energy X-ray absorptiometry will be used to quantify the percentage of body fat (%).	within 5 days from the start and end of training
Other	Bone Mass Density	Dual-energy X-ray absorptiometry will be used to quantify femur bone mass density (g/cm2).	within 5 days from the start and end of training
Other	Bone Mineral Content	Dual-energy X-ray absorptiometry will be used to quantify bone mineral content (g).	within 5 days from the start and end of training
Primary	Force Output	Force plate will be used to quantify maximum absolute (N) and relative force output (body mass divided per force output in N/kg) during maximum voluntary isometric back squat in a 100ms time frame. Participants will be pushing as hard and as fast as they can on an unmoveable barbell while standing on a force plate.	Immediately pre and post first and last training session
Primary	One-Repetition Maximum	One-Repetition Maximum test in leg press exercise will be performed to quantify maximum lower body dynamic strength (kg). Participants will be performing single repetitions of leg press exercise with increasing load until volitional failure.	within 5 days from the start and end of training
Primary	Maximum Number of Repetitions	A maximum number of repetitions in leg press exercise will be performed to quantify lower body strength endurance (number). Participants will be performing leg press exercise at 50% of one-repetition maximum until volitional failure.	within 5 days from the start and end of training
Primary	Countermovement Jump Height	Countermovement jump height will be performed estimated via take-off velocity performed on force plates to Participants will perform 3 trials on force plate.	Immediately pre and post first and last training session
Primary	Countermovement Jump Power Output	Countermovement jump performance will be performed to quantify maximum lower body relative and absolute power-output (W/kg and W), and jump height (cm) with concomitant assessment of contraction depth (cm) and contraction time (ms). Participants will perform 3 trials on force plate.	Immediately pre and post first and last training session
Primary	Catecholamine Response	A blood sample will be analyzed to quantify changes in epinephrine and norepinephrine level changes.	Immediately pre and post first and last training session
Primary	Muscle Stiffness	Myotonometry measure will be used to quantify changes in vastus medialis oblique muscle stiffness in N/m	Immediately pre and post first and last training session
Primary	Muscle Thickness	Ultrasonography measure will be used to quantify changes in vastus medialis oblique cross-sectional area.	within 5 days from the start and end of training
Secondary	Perception of Pain	A visual analogue scale will be used to quantify the perception of pain (units on a scale).	Immediately pre and post every training session
Secondary	Perception of Effort	The rate of perceived exertion scale will be used to quantify the perception of effort (units on a scale).	Immediately pre and post every training session
Secondary	Blood Pressure	Systolic and diastolic blood pressure will be measured to quantify blood pressure responses.	Immediately pre and post first and last training session