Resistance Exercise Clinical Trial
Official title:
Skeletal Muscle Protein Synthesis After Performance of Traditional and Cluster Set Configurations in Resistance-Trained Young Adults
NCT number | NCT04028726 |
Other study ID # | 16987 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | August 25, 2018 |
Est. completion date | July 15, 2019 |
Verified date | July 2019 |
Source | University of Illinois at Urbana-Champaign |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Traditionally, when performing resistance exercise, repetitions are performed in a continuous
manner resulting in a decrease in velocity, and thus power output. "Cluster" set is an
alternative to counter the reduction in velocity and power output. Cluster sets incorporate a
brief rest (15-30 seconds) between individual repetitions (inter-repetition rest) or group of
repetitions (intra-set rest) within a set of resistive exercise. In contrast to traditional
set configurations, which result in an almost linear decrease in force, velocity, and power
-cluster sets maintain and/or attenuate the loss in power, primarily due to higher
velocities.
The purpose of this research is to compare the muscle protein synthesis response to acute
bouts of cluster and traditional set configurations. Investigators will assess muscle protein
synthesis rates before and after acute resistance exercise in 14 resistance-trained males and
females (Age: 20-35; back squat 1.5 x body weight; 3 years of resistance training
experience). The volunteers are required to be removed (at least six weeks) from all
ergogenic levels of nutritional supplements that have previously been shown to affect protein
synthesis. Blood and muscle biopsies will be collected as a part of testing. Further,
subjects will be required to perform moderate-to-high intensity resistance exercise.
Status | Completed |
Enrollment | 8 |
Est. completion date | July 15, 2019 |
Est. primary completion date | October 25, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Resistance-trained adults - Back squat 1.5x body weight - 3 years resistance-training experience - Aged between 20-35 years Exclusion Criteria: - Tobacco use (previous 6 months) - Alcohol consumption >10 drinks per week - Metabolic disorders, diabetes, thyroid disease, hypogonadism - Heart disease, arrhythmias, asthma - History of uncontrolled hypertension - Orthopaedic injury/surgery within the last year - Hepatorenal, musculoskeletal, autoimmune, neuromuscular, or neurologic disease - Consumed ergogenic levels of nutritional supplements that may affect muscle mass (i.e. creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (i.e. DHEA) within six weeks prior to the onset of the study - Individuals consuming thyroid, androgenic, or other medications known to affect endocrine function - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti- inflammatories, or prescription strength acne medications) - Pregnant |
Country | Name | City | State |
---|---|---|---|
United States | Freer Hall | Urbana | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Illinois at Urbana-Champaign | Texas Christian University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Fractional Synthetic Rate of Myofibrillar Proteins | Myofibrillar muscle protein synthesis rates will be assessed during the 2hr Postabsorptive period (e.g. non-fed state) and the 5hr postprandial period (e.g. fed state) for both experimental interventions (e.g. leucine and leucine peptide). This will allow us to assess the change in fractional synthetic rate from the Postabsorptive period to the postprandial period. | Postabsorptive for 2 hours, Postprandial for 5 hours |
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