Chronic Periodontitis Clinical Trial
Official title:
Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection: Randomized Clinical Trial.
The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.
Periodontitis in a chronic disease caused by bacteria present in the subgingival flora, which
induces an inflammatory response of periodontal tissues. It has been suggested that some
periodontal pathogens may be inaccessible to mechanical periodontal therapy due to its
ability to invade the gingival tissues and evade defense mechanisms of the host. Therefore,
it is conceivable that coadjuvant administration of antimicrobials may improve the outcome of
mechanical therapy. There are several techniques to monitor periodontal pathogens and
determine antibiotic therapy. But the most important disadvantage of conventional laboratory
methods is that they are indirect, based on the molecular detection of 3 to 10 bacterial
species, without analyzing whether the biofilm as a whole is sensitive or resistant to
treatment, being a possible cause of failure and / or recurrence of the disease, in addition
to the risk of development of antimicrobial resistance.
The investigators hypothesis is that the specific selection of antimicrobial treatment with
the xCELLigence system allows better improvements in clinical parameters than indirect
laboratory methods.
Materials and methods:
A randomized double-blind clinical trial will be launched. Samples of subgingival plaque will
be taken with paper tips. Subjects included in the study will be randomized to one of 3
treatment groups: scaling and root planing combined with systemically administration of
antibiotic suggested by the xCELLigence system; scaling and root planing combined with
systemically administration of antibiotic suggested by 'Echevarne' laboratory and scaling and
root planing combined with systemically administration of antibiotic suggested by 'Origen'
laboratory.
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