Resectable Pancreatic Cancer Clinical Trial
Official title:
Phase II Study of Preoperative FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel in Patients With Resectable Pancreatic Cancer
This research study is a Phase II clinical trial, which evaluates a combination of drugs, FOLFIRINOX and Gemcitabine/Nab-Paclitaxel, in the management of participants with resectable pancreatic cancer prior to surgery.
Patients who fulfill eligibility criteria will be randomized to Arm A or Arm B
- Treatment will be administered on an outpatient basis.
- Upon registration participants will be randomized to Arm A (FOLFIRINOX) or Arm B
(Gemcitabine/nab-Paclitaxel).
- After completion of FOLFIRINOX or Gemcitabine/Nab-paclitaxel, all participants without
progressive disease will proceed to radiation therapy with capecitabine .
- Between 2 and 4 weeks after radiation is complete, participants will proceed for
surgical resection of pancreatic cancer
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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