Recall by Genotype: Neuropeptide Stimulation

Status Enrolling by invitation

Clinical Trial Summary

The objective of this protocol is to assess response to kisspeptin and gonadotropin-releasing hormone (GnRH) stimulation testing as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals who carry variants in genes related to infertility.

Clinical Trial Description

Assignment: All study subjects will undergo the same interventions. Individuals at high risk for infertility (i.e., carry variants in genes related to infertility) will be compared to controls (i.e., those who do not carry variants in genes related to infertility). Delivery of Interventions: - Prior to the inpatient study visit, the subjects will undergo a review of their medical history, physical exam, and screening laboratories. - On the day of the study, the subjects will have an intravenous (IV) line placed and - Undergo up to q10 min blood sampling x 12 hours - Receive a single kisspeptin IV bolus at hour 8 - Receive a single GnRH IV bolus at hour 11 ;

Study Design

Related Conditions & MeSH terms

Reproductive Disorder

Clinical Trial Details

NCT number	NCT05901467
Study type	Interventional
Source	Massachusetts General Hospital
Contact
Status	Enrolling by invitation
Phase	Phase 1
Start date	October 20, 2023
Completion date	December 31, 2025

View Details

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