Reperfusion Injury Clinical Trial
Official title:
Does Pretreated Magnesium Protect Against Reperfusion Injury in Liver Transplanted Patients?
The purpose of this study is to evaluate the effect of intravenous magnesium infusion before reperfusion with employing some clinical parameters including blood lactate levels, because the intraoperative changes in the blood lactate levels after hepatic allograft reperfusion served as an accurate predictor of the initial graft function in living donor liver transplantation.
Clinically significant hemodynamic deterioration occurs immediately after reperfusion of the
grafted liver by unclamping of the portal vein. Profound hypotension, bradycardia, systemic
vasodilation, and a decrease in cardiac output have been reported, and this is described as
postreperfusion syndrome (PRS). This hemodynamic instability usually requires adequate and
aggressive cardiovascular pharmacologic management and fluid support, and recovers slowly
over a period of 30 to 60 minutes.Because the severity of PRS correlates with patient and
allograft outcome, prevention of its occurrence or attenuation of the hemodynamic changes
may improve outcome. However, not much is known about how to protect against this
reperfusion injury.
Reperfusion injury also occurs in myocardial infarction, ischemic spinal cord injury and
stroke. Recent experiments have shown protective effects of magnesium to reduce the
reperfusion injury of these conditions. Magnesium administration may provide cellular
protection during ischemia and reperfusion with stabilizing the cellular transmembrane
potential, suppressing excessive cellular calcium influx and energy demand.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02251041 -
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
|
Phase 2 | |
| Completed |
NCT01944605 -
Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest
|
N/A | |
| Completed |
NCT00778323 -
Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery
|
Phase 1/Phase 2 | |
| Completed |
NCT00529607 -
Diagnostics for the Reperfusion Injury Following MI
|
N/A | |
| Completed |
NCT02731651 -
Effect of Pneumoperitoneum on Human Ovary
|
N/A | |
| Completed |
NCT02286544 -
Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers
|
Phase 1 | |
| Active, not recruiting |
NCT00189007 -
Antenatal Allopurinol During Fetal Hypoxia
|
Phase 3 | |
| Completed |
NCT01167569 -
Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients
|
Phase 4 | |
| Completed |
NCT00246740 -
Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting
|
Phase 2 | |
| Enrolling by invitation |
NCT05725694 -
Acute Ischaemic STROKE: From LAboratory to the Patient's BED
|
||
| Completed |
NCT00402506 -
A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG
|
Phase 3 | |
| Completed |
NCT03176823 -
Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury
|
N/A | |
| Completed |
NCT02512640 -
Comparison of Oxidative Stress Changes in Different Ventilation Strategies During Gynecologic Laparoscopic Surgery
|
N/A | |
| Recruiting |
NCT05574296 -
Hydrogen's Feasibility and Safety as a Therapy in ECPR
|
Phase 1 | |
| Active, not recruiting |
NCT02127996 -
GLP-1 Loading During Elective Percutaneous Coronary Intervention
|
Phase 2 | |
| Suspended |
NCT02850471 -
Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery
|
Phase 1/Phase 2 | |
| Terminated |
NCT02394405 -
Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
|
||
| Completed |
NCT00516711 -
Role of Volatile Anesthetics for Hepatic Protection
|
N/A | |
| Terminated |
NCT04316468 -
Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation
|
||
| Not yet recruiting |
NCT05676957 -
Reperfusion With Hypothermia in Acute Ischemic Stroke
|
N/A |