Role of Volatile Anesthetics for Hepatic Protection

Status Completed

Clinical Trial Summary

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Clinical Trial Description

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Reperfusion Injury

Clinical Trial Details

NCT number	NCT00516711
Study type	Interventional
Source	University of Zurich
Contact
Status	Completed
Phase	N/A
Start date	March 2006
Completion date	December 2007

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02251041` - Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)	Phase 2
Completed	`NCT01944605` - Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest	N/A
Completed	`NCT00529607` - Diagnostics for the Reperfusion Injury Following MI	N/A
Completed	`NCT00778323` - Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery	Phase 1/Phase 2
Completed	`NCT00994981` - Magnesium Administration in Liver Transplantation and Reperfusion Injury	Phase 4
Completed	`NCT02286544` - Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers	Phase 1
Completed	`NCT02731651` - Effect of Pneumoperitoneum on Human Ovary	N/A
Active, not recruiting	`NCT00189007` - Antenatal Allopurinol During Fetal Hypoxia	Phase 3
Completed	`NCT01167569` - Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients	Phase 4
Completed	`NCT00246740` - Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting	Phase 2
Enrolling by invitation	`NCT05725694` - Acute Ischaemic STROKE: From LAboratory to the Patient's BED
Completed	`NCT00402506` - A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG	Phase 3
Completed	`NCT03176823` - Remote Ischemic Conditioning as a Treatment for Traumatic Brain Injury	N/A
Completed	`NCT02512640` - Comparison of Oxidative Stress Changes in Different Ventilation Strategies During Gynecologic Laparoscopic Surgery	N/A
Recruiting	`NCT05574296` - Hydrogen's Feasibility and Safety as a Therapy in ECPR	Phase 1
Active, not recruiting	`NCT02127996` - GLP-1 Loading During Elective Percutaneous Coronary Intervention	Phase 2
Suspended	`NCT02850471` - Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery	Phase 1/Phase 2
Terminated	`NCT02394405` - Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Terminated	`NCT04316468` - Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation
Not yet recruiting	`NCT05676957` - Reperfusion With Hypothermia in Acute Ischemic Stroke	N/A