Renal Tumor Clinical Trial
The multimodal analgesia for postoperative pain aims for optimal analgesia through additive
or synergic drug effects. The multimodal analgesia results in the use of smaller doses of
opioids and lowering opioid-related side effects.
Non-opioid analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), propacetamol (prodrug
of acetaminophen), nefopam are often given along with opioids as part of multimodal
analgesia after major surgery.
NSAIDS, commonly used non-opioid analgesics, have gastro-intestinal, renal, and cardiac side
effects.
In contrast, propacetamol or nefopam, two drugs with central analgesic effects, can be
safely used as analgesic adjuvants with opioid after nephrectomy, because these drugs do not
alter renal function or cause hemorrhagic complications.
Recent study demonstrated that the antinociceptive properties of paracetamol (intravenous
acetaminophen) associated with the analgesic effectiveness of nefopam could explain the
observed synergy of the combination.
The aim of this randomized, double-blinded study is to compare the opioid-sparing effect and
analgesic efficacy, as well as quality of recovery, of nefopam-propacetamol combination and
propacetamol in patients undergoing laparoscopic nephrectomy.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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