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Combined Kidney and Hematopoietic Stem Cell Transplantation for Tolerance Induction

Renal Transplantation Clinical Trial

Official title:
Combined Kidney and Hematopoietic Stem Cell Transplantation for Tolerance Induction Between Matched Sibling Donor-recipient Pairs

Clinical Trial Summary

Combined transplantation of kidney and bone marrow between HLA-matched sibling donor-recipient pairs to induce immune tolerance in order to enable complete discontinuation of immunosuppressive therapy without kidney rejection. Hematopoietic stem cells are collected from the donor 4 to 8 weeks before kidney transplantation, CD34 cells are enriched by positive selection and cryopreserved. The day after kidney transplantation the recipient starts conditioning therapy with thymoglobuline, total lymphoid irradiation, steroids, tacrolimus and mycophenolate mofetil. Eleven days after kidney transplantation the stem cell graft is thawed and infused to the recipient. If mixed donor chimerism is successfully maintained more than 6 months without rejection, then immunosuppression may be tapered off until complete discontinuation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05086003
Study type Interventional
Source Rabin Medical Center
Contact Moshe Yeshurun, MD
Phone 0526015543
Email moshe.yeshurun@gmail.com
Status Recruiting
Phase Phase 2
Start date January 19, 2016
Completion date December 31, 2026
View Details
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