Renal Transplantation Clinical Trial
Official title:
Protective Effect of N-acetylcysteine on Early Outcomes of Deceased Renal Transplant
Investigate the therapeutic effects of the antioxidant N-acetylcysteine on early outcomes of deceased renal transplant patients.
Investigate the therapeutic effects of 600 mg bid po of N-acetylcysteine on early outcomes
of deceased renal transplant patients regarding oxidative stress and renal function.
Adult primary graft recipients of deceased renal donors will be randomly assign to treatment
(NAC) or control group and prospectively evaluated for 90 days. Treatment group will receive
N-acetylcysteine 600 mg bid po from 0 to 7th postoperative day (PO). Renal function will be
determined by serum creatinine, Cockroft-Gault estimated GFR (eGFR) at 7th, 15th, 30th, 60th
and 90th PO and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric
acid reactive substances (TBARS), which are markers of lipid peroxidation and oxidative
stress, will be determined using the thiobarbituric acid assay from 0-7th PO. Statistical
analysis will be performed using SPSS 16.0.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
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