Intravenous Voriconazole in Patients With Renal Compromise

Status Completed

Clinical Trial Summary

Clinical Trial Description

The purpose of this study is to determine whether patients with compromised renal function (CrCl < 50mL/min) receiving intravenous voriconazole experienced any adverse effects related to serum chemistries or other imaging studies of the kidney due to the potential accumulation of the vehicle cyclodextran. t has been previously shown by a large multi-centered, prospective, randomized study that voriconazole is superior to the then gold standard amphotericin B in the treatment of patients with invasive aspergillosis - a disease with significant morbidity and mortality. In patients with these infections who have severe renal insufficiency may be denied the best therapy due to the accumulation of a diluent with unknown clinical consequences. Qualifying and or quantifying these consequences are important to these patients so that potentially life-threatening therapy should not be unduly denied. ;

Study Design

Related Conditions & MeSH terms

Renal Transplant

Clinical Trial Details

NCT number	NCT00332410
Study type	Observational
Source	University of Pittsburgh
Contact
Status	Completed
Phase
Start date	May 2006
Completion date	December 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01220050` - Paricalcitol in Reducing Parathyroid Hormone Levels and Ameliorating Markers of Bone Remodelling in Renal Transplant Recipients With Secondary Hyperparathyroidism	Phase 2
Completed	`NCT00820469` - Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab	Phase 4
Completed	`NCT00239005` - Enteric-Coated Mycophenolate Sodium on Quality of Life in Patients With Gastrointestinal Symptoms Related to Mycophenolate Mofetil Therapy After Kidney Transplantation	Phase 4
Completed	`NCT00270153` - The Use of ACE Inhibitors in the Early Renal Post-transplant Period	Phase 1
Completed	`NCT02711826` - Treg Therapy in Subclinical Inflammation in Kidney Transplantation	Phase 1/Phase 2
Completed	`NCT03837522` - Trial to Define the Benefits and Harms of Deceased Donor Kidney Procurement Biopsies	N/A
Not yet recruiting	`NCT06025240` - Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
Completed	`NCT01256294` - Pharmacokinetics of Generic to Brand Tacrolimus in Stable Renal Transplant Patients	Phase 4
Suspended	`NCT01059292` - TIPE2 Associated With Kidney Transplant	N/A
Completed	`NCT00547040` - Arterial Stiffness and Calcifications in Incident Renal Transplant Recipients
Suspended	`NCT03043339` - Characterization Of the Intestinal Microbiome Evolution After Kidney Transplant Donation or Receipt
Completed	`NCT02581644` - Assessment of Effectiveness of Belatacept Patient Alert Card in Patients Following Renal Transplantation in a Sample of EU Countries	N/A
Completed	`NCT01728012` - Long-term Cardiovascular Risk Following Successful Renal Transplantation	N/A
Terminated	`NCT01011114` - Using Cinacalcet to Treat the Hypophosphatemia of Early Kidney Transplant	N/A
Completed	`NCT02117596` - Calcineurin Inhibitor Based Immunosuppression Withdrawal	N/A
Completed	`NCT00555373` - Pediatric Kidney Transplant Study of Sirolimus, Mycophenolate Mofetil, and Corticosteroids vs Calcineurin Inhibitor Based Immunosuppression	N/A
Recruiting	`NCT05156086` - Safety and Effectiveness of COVID-19 Vaccine in Kidney Transplant Recipients
Completed	`NCT01334333` - Comparison of Medication Adherence Between Once and Twice Daily Tacrolimus in Stable Renal Transplant Recipients	Phase 4
Recruiting	`NCT03107858` - The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function	Phase 2/Phase 3
Completed	`NCT00352547` - Influence of Genes on Sirolimus Metabolism in Patients With Kidney Transplantation	N/A