Renal Insufficiency, Chronic Clinical Trial
Official title:
Effect of Kidney Yin/Yang Replenishment on Bone Metabolism in Patients With Renal Osteodystrophy
Patients with serious chronic renal insufficiency usually develop secondary osteoporosis or bone loss, especially those with chronic dialysis, and the degree of bone loss is corrected with decrease of renal function. In traditional Chinese medicine, kidney function is considered to dominate bone development and metabolism. Kidney Yin and Yang replenishment will help improve bone development and metabolism.
In this study patients with chronic renal insufficiency and secondary osteoporosis or bone
loss will be evaluated with traditional Chinese medicine standard and allocated into kidney
Yin deficiency and kidney Yang deficiency groups. In Yin deficiency group, patients will be
divided into Zuogui granules treatment group and placebo group. In Yang deficiency group,
patients will be divided into Yuogui granules treatment group and placebo group. All the
patients will also accept basic treatment.
After 3-month-treatment, we will detect blood urea nitrogen, creatinine, bone mineral
density, bone metabolism markers including FGF23, 1,25(OH)2D3, Osteocalcin, PTH, BALP, serum
and urinal Ca, P. We will also perform miRNA array. The data before treatment and after
treatment will be compared. The data of treatment groups and placebo groups will also be
compared.
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