Clinical Trials Logo

Clinical Trial Summary

It is unclear whether different modes of continuous renal replacement therapy (CRRT) impact post-filter ionized calcium concentrations during regional citrate anticoagulation (RCA) when using calcium-containing replacement fluid. This prospective, single-center, observational cohort study will screen all patients receiving CRRT for eligibility. General clinical information will be collected before commencing CRRT treatment. Patients will be randomly assigned to either the veno-venous hemofiltration (CVVH) or continuous veno-venous hemodialysis (CVVHD) group and switch to the alternative mode in the subsequent treatment session. Pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent total and ionized calcium will be measured 2 hours after the initiation of CRRT. Electrolyte levels, arterial blood gases, hourly citrate dose, and total citrate dose will be recorded every 6 hours until the end of CRRT. The primary outcome is the difference in ionized calcium concentrations at each site over time between the two modes.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06021080
Study type Observational [Patient Registry]
Source Fujian Provincial Hospital
Contact Han Chen, Ph.D., M.D.
Phone +86 591 88217010
Email hanchen.cn@icloud.com
Status Recruiting
Phase
Start date June 9, 2023
Completion date December 9, 2024

See also
  Status Clinical Trial Phase
Terminated NCT03940651 - Cardiac and Renal Biomarkers in Arthroplasty Surgery Phase 4
Completed NCT05092854 - The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress N/A
Not yet recruiting NCT04078711 - Chinese Medicine Treat for Hypertensive Renal Injury Phase 2/Phase 3
Not yet recruiting NCT06109714 - Early Biomarker Kidney Injury Assessment After Acumen Directed Fluid Management in Cardiac Surgery N/A
Completed NCT03273751 - The Effect of Remote Ischemic Preconditioning on Kidney Function in Patients Undergoing Partial Nephrectomy N/A
Recruiting NCT04580329 - The Effect of Neuromuscular Electrical Stimulation (NMES) on the Renal Function and Renal Blood Flow N/A
Active, not recruiting NCT04070482 - Impact of in Utero and Breastfeeding Exposure to Tenofovir on Renal Function in HIV-exposed Uninfected Children
Completed NCT02660931 - Pediatric Acute Kidney Injury (AKI) Retrospective, Real-Time and Repository Research N/A
Not yet recruiting NCT06116383 - Evaluation of Renal Perfusion With NIRS in Laparoscopic Surgery
Recruiting NCT06056466 - Different Vascular and Renal Parameters in Living Kidney Donors
Completed NCT01925235 - Analysis of Remote-ischemic Preconditioning Effects on Kidney Function N/A
Completed NCT03877133 - Association of Intraoperative Renal Regional Oxygen Saturation and Acute Kidney Injury N/A
Not yet recruiting NCT05276700 - Alpha -1- Microglobulin (α1M) as an Early Biomarker in Renal Extrahepatic Manifestations of HCV-infection
Recruiting NCT06203145 - A Clinical Study on the Whole-course Management (BCD-KPD-AutoHSCT) Scheme for Patients With RIMM N/A
Recruiting NCT04937868 - Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients
Completed NCT05358912 - Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock Phase 4
Completed NCT02221219 - Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Phase 1/Phase 2
Active, not recruiting NCT00855036 - Prospective Evaluation of Blunt Renal Injury in Children
Completed NCT04695951 - Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract Phase 2
Recruiting NCT04265599 - Exploring Pathogenesis and Treatment of Hypercalcemia Caused by Intramuscular Injection of Paraffinoil