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NCT06407375 Clinical Trial

Assessment of Renal Function by Multiparametric MRI

Renal Impairment Clinical Trial

Official title:
Assessment of Renal Function by Multiparametric MRI

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06407375
Other study ID # mpMRI Kidney
Secondary ID
Status Recruiting
Phase Early Phase 1
First received
Last updated
Start date May 1, 2023
Est. completion date October 1, 2025

Study information
Verified date May 2024
Source University of Zurich
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Metabolic syndrome is a collection of conditions that affect at least three of the following five criteria: abdominal obesity, high blood pressure, high fasting glucose levels, high triglyceride levels, and low levels of high-density lipoprotein (HDL) cholesterol. Chronic kidney disease (CKD) is a common complication of metabolic syndrome, with an estimated prevalence of 13-40%. Early diagnosis of progressive conditions before the onset of reduced glomerular filtration rate (GFR) or albuminuria may be of clinical benefit but is not possible at present. Furthermore, the diagnosis and quantification of CKD in the context of metabolic syndrome is challenging due to the lack of reliable diagnostic biomarkers, and the current methods may not accurately reflect kidney function in patients with metabolic syndrome. Magnetic resonance imaging (MRI) has been sparsely explored as a potential tool to assess renal perfusion, oxygenation, and fibrosis. Multiparametric MRI (mpMRI) combines several different imaging techniques to provide a more comprehensive evaluation of tissue structure and function. These techniques hold promise for non-invasive assessment of kidney function, but their clinical utility is still largely experimental. Therefore, we aim to conduct an exploratory study to investigate the reliability, reproducibility as well as the validity of parameters for kidney function of multiparametric MRI as well as compare these parameters in between healthy patients and patients with metabolic syndrome.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date October 1, 2025
Est. primary completion date May 1, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Diagnosed metabolic syndrome Exclusion Criteria: - MRI exclusion criteria

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• mpMRI
mpMRI

Locations
Country Name City State
Switzerland University Hospital Zurich Zurich ZH

Sponsors (1)
Lead Sponsor Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Glomerula Filtration Rate 05/2025
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