Hemodynamic Instability Clinical Trial
Official title:
Phase 4 THE EFFECTS OF DEXMEDETOMIDINE ON EARLY STAGE RENAL FUNCTIONS IN PEDIATRIC PATIENTS UNDERGOING CARDIAC ANGIOGRAPHY USING NON- IONIC CONTRAST MEDIA: A DOUBLE- BLIND, RANDOMIZED CLINICAL TRIAL
The aim of this study is to evaluate the effect of dexmedetomidine infusion on early stage renal function.
Background: Contrast-induced nephropathy is the third most common cause of acute renal
failure in hospitalized patients in all age groups. In this study we aimed to investigate
the effects of dexmedetomidine on early stage renal function in pediatric patients
undergoing cardiac angiography.
Methods: 60 pediatric patients between 6 and 72 months of age undergoing cardiac angiography
were included in the study. Patients were divided into two groups. The patients in both
groups were administered 1mgkg-1 ketamine, 1mgkg-1 propofol as bolus and followed by 1
mgkg-1hour-1 ketamine and 50 µgkg-1min-1 propofol infusion. Additionally, a loading dose of
1 µgkg-1 dexmedetomidine given over 10 minutes followed by 0.5 µgkg-1hour-1 dexmedetomidine
infusion to patients in group D. The patients were evaluated for NGAL, creatinine, renin,
endothelin-1, TAS and TOS blood levels before the procedure and 6th and 24th hours after the
procedure. pRIFLE criteria were used to define CIN and its incidence in the study.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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