Cardiac Surgery Clinical Trial
Official title:
Renal Resistive Index Compared With NephroCheckTM to Predict Postoperative Acute Renal Failure in Patients Undergoing Cardiac Surgery.
Postoperative acute renal failure is a frequent complication after cardiac surgery. The
current practice cannot predict Acute Kidney Injuries (AKI) early enough to reduce a
significant kidney assault and prevent an organic dysfunction leading to cortical tubular
necrosis.
Several recent studies in cardiac surgery have shown that, both sonographic criteria, such
as the Renal Resistive Index (IRR) and urinary biomarkers can predict AKI promptly. These
urinary biomarkers are the 'tissue inhibitor of metalloproteinases' (TIMP-2) and the
'insulin-like growth factor binding protein' (IGFBP7). These two proteins are sought
noninvasively, directly in the urine, within the same test called 'NephroCheckTM'. These
markers, ultrasonographic and biologic, have the advantage of being easy to perform,
accessible and seem to have both high sensitivity and specificity to predict AKI promptly
after cardiac surgery. Thus, the IRR and the NephroCheckTM test could become essential tests
to guide clinicians in determining rapidly whether a patient will develop AKI. However, so
far, no study has compared these markers yet.
Therefore, the aim of this prospective observational study will be to compare the
effectiveness of the IRR with the NephroCheckTM to predict AKI promptly after cardiac
surgery. The secondary outcome will be to determine the threshold of these markers from
which patients will be likely to develop AKI
n/a
Observational Model: Cohort, Time Perspective: Prospective
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