Renal Failure Clinical Trial
Official title:
The Role of Hemodynamics, Cytokine Response, and Modulators of Apoptosis on Urine Output in Patients With Acute Renal Failure on CVVH
Acute kidney failure is common in children in the Pediatric Intensive Care Unit (PICU). You are being asked to participate in this study because your child is being treated for kidney failure with continuous veno-venous hemofiltration (CVVH). CVVH is a continuous, gentle form of removing excess fluids and small wastes from the blood, similar to kidney dialysis (artificial kidney). It is an accepted therapy for temporary support of kidney failure. In some patients with acute kidney failure, beginning CVVH is followed by a temporary decrease of urine output. The reason why this happens is currently unknown. The purpose of this study is to determine why this happens.
Acute renal failure is common in children in the pediatric intensive care unit. Renal
replacement therapies such as peritoneal dialysis (PD), intermittent hemodialysis (IHD), and
continuous venovenous hemofiltration (CVVH) have been used in the management of acute renal
failure. CVVH is becoming increasingly utilized in pediatric acute renal failure. However,
in patients who have acute renal failure, the institution of CVVH is often followed by a
progression to oliguria or anuria. The underlying pathophysiology of this change is unknown.
We believe that this progression is influenced by changes in the renin-angiotensin axis,
cytokine response, and other modifiers of renal hemodynamics. By serially measuring
components of those systems, this study will attempt to elucidate the pathophysiology of the
decreased urine output seen with institution of CVVH. Once this process is understood,
future studies should focus on prevention and treatment of this complication.
General Hypothesis
The decrease in urine output seen after the initiation of CVVH is associated with increased
angiotensin converting enzyme (ACE) levels, increased renin activity, increased angiotensin
II levels, increased atrial naturetic peptide (ANP) levels, increased endothelin-1 levels,
increased arginine vasopressin (AVP) levels, and alterations of cytokine levels and
modulators of apoptosis.
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Observational Model: Cohort, Time Perspective: Prospective
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