Renal Disease Clinical Trial
Official title:
Role of Diffusion Weighted Magnetic Resonance Imaging in Evaluation of Chronic Kidney Disease
Chronic kidney disease (CKD) is a common global public health problem and the average incidence of end-stage renal disease in developing countries is 150 per million population, which is lower than that in the developed world
Since renal parenchymal disease is accompanied by renal dysfunction, monitoring renal
function permits assessment of disease progression, and periodic assessment of renal function
is necessary for optimal management of a patient with suspected/proven renal disease. Serum
creatinine (S Cr), blood urea (BU), and estimated glomerular filtration rate (eGFR) derived
from creatinine clearance are useful for monitoring renal function; however, these indirect
measures of renal filtration are imperfect and cannot assess single kidney function.
Keeping in view the limitations of serum markers, imaging may play an important role in the
evaluation of renal parenchymal disease. Ultrasonography (US) and computed tomographic (CT)
scan provide good anatomic images but limited functional information. Although US may show
changes in renal echogenicity, it suffers from operator dependency and lacks objectivity. In
addition to exposure to ionizing radiation, computed tomography (CT) scan requires use of
iodinated contrast material, which is undesirable in patients with renal dysfunction.
Magnetic resonance imaging (MRI) has the unique ability to show both structure and function
objectively without any radiation exposure to the patient. Functional MRI techniques such as
diffusion-weighted imaging (DWI), blood oxygen level-dependent (BOLD) imaging have potential
utility in the evaluation of renal function .
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