Renal Cell Carcinoma Clinical Trial
Official title:
Monitoring Disease Burden and Biology Using Tumor Cell Free DNA in Metastatic Kidney Cancer
This study will assess whether DNA released by kidney cancer into the blood stream and urine of patients can be used to monitor tumor burden and tumor response to treatment in patients receiving immunotherapy
| Status | Recruiting |
| Enrollment | 150 |
| Est. completion date | February 2026 |
| Est. primary completion date | February 2025 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Renal Cell Carcinoma with clear cell component - Stage IV - Receiving IO-containing regimen - Measurable disease per RECIST 1.1 Exclusion Criteria: - Active cancer (exclusion criteria only for healthy patient cohort) |
| Country | Name | City | State |
|---|---|---|---|
| United States | The University of Texas MD Anderson Cancer Center | Houston | Texas |
| United States | Tennessee Valley Health Care System | Nashville | Tennessee |
| United States | Vanderbilt University Medical Center | Nashville | Tennessee |
| Lead Sponsor | Collaborator |
|---|---|
| Vanderbilt-Ingram Cancer Center | United States Department of Defense |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Evaluate tumor cfDNA as a dynamic marker of response to IO therapy | Measure of changes in the amount of tumor DNA correlated with result of routine tumor imaging studies | Up to about 2 years |
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|---|---|---|---|
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