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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT00001238
Other study ID # 890086
Secondary ID 89-C-0086
Status Recruiting
Phase
First received
Last updated
Start date December 5, 1990

Study information

Verified date June 6, 2024
Source National Institutes of Health Clinical Center (CC)
Contact Deborah A Nielsen, R.N.
Phone (240) 760-6247
Email deborah.nielsen@nih.gov
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

We will investigate the clinical manifestations and molecular genetic defects of heritable urologic malignant disorders. Families with urologic malignancy with known or suspected genetic basis will be enrolled. Affected individuals or individuals suspected of having a germline urologic malignant disorder will undergo periodic clinical assessment and genetic analyses for the purpose of: 1) definition and characterization of phenotype, 2) determination of the natural history of the disorder, and 3) genotype/phenotype correlation. Genetic linkage studies may be performed in situations in which the genetic basis of the disorder has not been elucidated. ...


Description:

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Other known NCT identifiers
  • NCT00019617

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Study Design


Locations

Country Name City State
United States National Institutes of Health Clinical Center Bethesda Maryland

Sponsors (1)

Lead Sponsor Collaborator
National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Identify and describe as yet unknown or uncharacterized inherited urologic malignant disorders. Collection of blood, tissue & urine to address further scientific questions related to this protocol. on-going
Primary Determine the genetic etiology of hereditary urologic malignant disorders in which the gene variation is unknown, by linkage analysis, positional cloning and evaluation of candidate genes. Collection of blood, tissue & urine to address further scientific questions related to this protocol. on-going
Primary Correlate specific mutations and their associated protein domains with disease phenotypic expression based on parameters including presenting age, clinical manifestations, histopathology and rate of recurrence. Collection of blood, tissue & urine to address further scientific questions related to this protocol. on-going
Primary Characterize the natural and clinical histories of inherited urologic malignant disorders. Collection of blood, tissue & urine to address further scientific questions related to this protocol. on-going
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