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Renal Cell Carcinoma 4 clinical trials

View clinical trials related to Renal Cell Carcinoma 4.

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NCT ID: NCT01370109 Completed - Clinical trials for Renal Cell Carcinoma 4

Cardiovascular Effects of Sunitinib Therapy (CREST)

Start date: April 2011
Phase:
Study type: Observational

Tyrosine kinase inhibitors such as sunitinib are used in the treatment of renal cell carcinoma and have significant off-target effects with cardiac toxicity and resultant ventricular cardiac dysfunction being a major concern. However, the mechanisms of these effects in humans remains poorly defined, as are the clinical methods to risk stratify and identify patients who will ultimately suffer from cardiac dysfunction. The goal of this multi-center study is to characterize the cardiovascular measures of cardiac function; 2) comprehensive measures of arterial function and left ventricular afterload; 3) biomarkers reflective of the pathophysiologic alterations. Through this work, the investigators will translate our basic understanding of sunitinib cardiotoxicity to humans and identify early predictors of sunitinib cardiotoxicity.