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Renal Calculi clinical trials

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NCT ID: NCT02408211 Enrolling by invitation - Kidney Stones Clinical Trials

Preoperative Antibiotic PNL Study

Start date: March 2015
Phase: Phase 4
Study type: Interventional

Percutaneous nephrolithotomy (PCNL) is a surgical procedure that is standard of care for the removal of large kidney stones. PCNL involves removal of the stone(s) from the kidney through a temporary tract that is percutaneously placed through the patient's back during surgery. There is a significant risk of urinary tract infection after PCNL but wide clinical variation in use of prophylactic antibiotics in the days leading up to surgery. For patients who had already agreed to undergo PCNL, we plan to randomize them either to 1 week of preoperative antibiotic prophylaxis plus < 24 hours of perioperative IV antibiotics or to < 24 hours of perioperative IV antibiotics only. We will then compare the rates of infectious complications following PCNL for the two groups.

NCT ID: NCT01450566 Recruiting - Renal Calculi Clinical Trials

Intraureteral Lidocaine for Post-Ureteroscopy Pain

Start date: September 2011
Phase: N/A
Study type: Interventional

Ureteroscopy (URS) is minimally invasive procedure for management of renal stones. URS is often involves concomitant of an indwelling ureteral stents. Placements of these stents include pain, bladder irritability, infection, migration, encrustation and stones. Pain is one of most significant problem of ureteral stents. There are no satisfactory measures to deal with this problem. A novel approach to manage the pain is to load a drug onto ureteral stent and deliver the drug into the urinary tract at controlled release rate. Lidocaine has been proven to be effective for management of the pain associated with interstitial cystitis. This agent has the potential for management of post-URS pain.

NCT ID: NCT01437904 Completed - Renal Calculi Clinical Trials

A Pilot Study Assessing The Feasibility Of Outpatient Tubeless Percutaneous Nephrolithotomy (PCNL)

Start date: March 2011
Phase: N/A
Study type: Interventional

Outpatient tubeless Percutaneous nephrolithotomy (PCNL) could potentially improve patient care and result in significant cost savings for our hospital each year. If this pilot study is successful, Queen's/KGH will lead a collaborative national multicentre trial to further establish the role of this new approach in the surgical treatment of kidney stones.

NCT ID: NCT01355341 Unknown status - RENAL CALCULI Clinical Trials

Safety and Efficacy of Herbmed Plus in Patients withRenal Calculi

HerbmedPlus
Start date: April 2010
Phase: Phase 2
Study type: Interventional

More specifically, the present invention relates to a 'Herbal Preparation' that is useful for - Treatment of Renal calculi - Reduction in the stone size & surface area - The expulsion of stone - Decreased need of Analgesic(Antiinflammatory Effect) - Stops the recurrence and reformation of renal

NCT ID: NCT01215708 Active, not recruiting - Renal Calculi Clinical Trials

Effects of the Use of Adjuvant Drugs After Extracorporeal Shockwave Lithotripsy (ESWL) in Renal Calculus

Start date: August 2006
Phase: Phase 3
Study type: Interventional

The investigators objective is to study if some drugs can improve the success rate of extracorporeal shockwave lithotripsy for renal stones.

NCT ID: NCT01008267 Not yet recruiting - Renal Calculi Clinical Trials

Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia.

Start date: November 2009
Phase: N/A
Study type: Observational

SWL is widely used in the treatment of patients with renal and ureteral calculi. Several factors determine the success of extracorporeal shockwave lithotripsy (SWL) for kidney stones: stone size, stone location within the collecting system, stone type, and the SWL machine used. Moreover, in some cases it is very difficult to focus on the stone because of its movement as a results of breathing. In order to prevent stone movement we want to use a bronchial blocker, processing a selective ventilation of the opposite side of stone location.

NCT ID: NCT00893282 Completed - Kidney Stones Clinical Trials

Clinical Evaluation of BackStop in Patients Undergoing Intraureteric Stone Lithotripsy

Start date: February 2008
Phase: N/A
Study type: Interventional

The purpose of this clinical study is to evaluate BackStop, a polymer-based device that is intended to be used during ureteroscopic lithotripsy to prevent retrograde stone migration. It is a water soluble polymer with reverse thermosensitive properties; the polymer exists as a liquid at low temperature (below 17 C) and rapidly transitions to a high viscosity gel at body temperature (i.e. in the ureter). BackStop is injected above the stones in the ureter and is intended to prevent retrograde migration of stones during ureteroscopic lithotripsy. Upon completion of the lithotripsy procedure, BackStop dissolves naturally or by irrigation. The study hypothesis is that a greater proportion of patients will experience no retropulsion of a kidney stone when BackStop is used versus no anti-retropulsion device when undergoing intracorporeal lithotripsy.

NCT ID: NCT00857090 Completed - Kidney Stones Clinical Trials

Pharmacokinetic, Safety and Efficacy Study of OMS201 in Subjects Undergoing Retrograde Ureteroscopic Removal of Upper Urinary Tract Stones

Start date: March 2009
Phase: Phase 1/Phase 2
Study type: Interventional

The objectives of the study are to assess the systemic exposure, safety and efficacy of three concentrations of OMS201 in subjects undergoing retrograde ureteroscopic removal of upper urinary tract stones.

NCT ID: NCT00250406 Completed - Renal Calculi Clinical Trials

Assessment of Drug-eluting Ureteral Stent on Bacterial Adherence and Biofilm Formation

Start date: November 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the clinical effects of a triclosan stent on adherent bacteria, stent biofilms, and patient urine cultures in patients with an indwelling triclosan ureteral stent. The patient populations that will be tested include: patients following ureteroscopy and patients scheduled to undergo shockwave lithotripsy who require a ureteral stent. It is hypothesized that triclosan eluting ureteral stents will reduce the number of bacteria both on (within biofilm) and around (in the urine) a ureteral stent.

NCT ID: NCT00169806 Recruiting - Hyperparathyroidism Clinical Trials

Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis

Start date: November 1998
Phase: N/A
Study type: Interventional

Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understanding of what causes kidney stones is useful in both the treatment and prevention of kidney stones. However, exactly what causes kidney stones is unknown. The most common type of kidney stones contains calcium, which sometimes is attached to a part of the kidney important in producing the final urine, called the papilla. The investigators have noticed that persons who form kidney stones seem to have more papilla with stones attached. They propose to study these areas of the papilla, called Randall's plaques (named after their discoverer), in patients undergoing surgery for kidney stones.