Renal Artery Stenosis Clinical Trial
Official title:
Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study
Fibromuscular dysplasia (FMD) is localized structural defects in the arterial wall, whose
innate or acquired character is still unknown. This segmental non atheromatous injury, leads
to stenosis of the arteries of small and medium caliber. Renal arteries are the most
commonly affected with 60-75% of total fibrodysplasia. Three histological subtypes have been
described: intimal, medial and peri-medial. They are not mutually exclusive and can be
observed in the same patient.
This is a rare blood disease, occurring in children and young adults. In this young
population with long life expectancy, these aneurysmal lesion are associated with 10% risk
of rupture. To date, no data have shown in the literature that FMD is link to genetic
causes, or if there is specific histopathologic lesions for non-atherosclerotic renal artery
aneurysms.
To answer these questions, Cardiovascular Surgery Unit of the University Hospital of
Saint-Etienne, French national reference center for renal artery surgery, in association
with the Reference Center for Rare Vascular Disease in Paris, designed the first study for
pathological and genetic characteristics of dysplastic renal artery aneurysms in young
patients.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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