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Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder.

REM Sleep Behavior Disorder Clinical Trial

Official title:
Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder: a Case-control Family Study

Clinical Trial Summary

In this cohort study, the investigators aim to study the familial aggregation of REM sleep behavior disorder (RBD) and compare the differences in major biomarkers of neurodegeneration, including percentage of EMG activity during REM sleep, cognitive functions, autonomic dysfunction, and psychiatric disorders, between unaffected first degree relatives of RBD cases and non-RBD controls.

Clinical Trial Description

REM sleep behavior disorder (RBD) is a parasomnia characterized by abnormal behavioral manifestations during REM sleep. Previous case-control studies and prospective studies have documented the progression of α-synucleinopathy neurodegeneration in relation to RBD and have identified some biomarkers of predicting neurodegeneration in patients with iRBD, such as olfactory dysfunction, color vision deficit, autonomic dysfunction, tonic EMG activity during REM sleep, and psychiatric disorder. However, these biomarkers might precede the onset of RBD, as a result, searching for biomarkers for the neurodegeneration before RBD onset is helpful to map the progression of neurodegeneration. In this regard, the investigators aim to study the familial aggregation of RBD and its core features, and compare the differences in major biomarkers of neurodegeneration, including percentage of EMG activity during REM sleep, cognitive functions, autonomic dysfunction, and psychiatric disorders, between unaffected first degree relatives of RBD cases and non-RBD controls. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03660982
Study type Observational
Source Chinese University of Hong Kong
Contact Jihui Zhang, PhD
Phone (852) 39197647
Email jihui.zhang@cuhk.edu.hk
Status Recruiting
Phase
Start date October 1, 2014
Completion date September 30, 2022
View Details
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