Clinical Trials Logo

Clinical Trial Summary

Relapsing polychondritis (RP) is a rare, systemic autoimmune disorder characterized by episodic inflammation of cartilaginous structures. Pro-inflammatory chemokines involved in the recruitment of monocytes and modulation of macrophage function, such as monocyte chemoattractant protein-1, macrophage inflammatory protein 1β, and interleukin (IL)-8, are significantly elevated in active RP compared with controls.The activation of monocytes and macrophages may play an important role in the pathophysiology of RP. The levels of serum Th1 cytokines (interferon, IL-2 (IL-2) and IL-12 (IL-12) were significantly correlated with disease status,which suggested that RP may be a Th1-mediated disease process. IL-2 is a kind of lymphocyte growth factor. At lower doses, regulatory T cells exhibit dominant amplification because of their more sensitivity to IL-2. Regulatory T cells can inhibit the growth of effector T cells and then play an immunosuppressive role. The investigators hypothesized that low-dose IL-2 could be a novel therapy in active RP patients. This clinical study will explore the efficacy and immunological evaluation of low dose IL-2 in the treatment of RP.


Clinical Trial Description

Ten patients with active RP at 18 to 70 years of age were enrolled. Without changing the original treatment plan, IL-2 1 million units was administered subcutaneously five days every week for 4 weeks and then once a week for 8 weeks. The clinical symptoms, disease score scale, laboratory parameters, immune cell subsets and cytokines should be monitored during the treatment. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04077736
Study type Interventional
Source Peking University People's Hospital
Contact
Status Completed
Phase Phase 2
Start date November 1, 2019
Completion date October 30, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT02257866 - Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis
Withdrawn NCT01104480 - Tocilizumab for Relapsing Polychondritis Phase 2
Active, not recruiting NCT05168475 - Biologics in Refractory Vasculitis Phase 2
Completed NCT01272856 - Study on the Safety of Abatacept in Relapsing Polychondritis Phase 1
Completed NCT01041248 - Single Patient Study to Treat Relapsing Polychondritis With Tocilizumab N/A
Recruiting NCT04919538 - Longitudinal Study for Relapsing Polychondritis
Recruiting NCT06019221 - Pediatric Relapsing Polychondritis : Diagnosis and Management in a French Retrospective Study
Recruiting NCT03840928 - PatientSpot Formerly Known as ArthritisPower