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Relapsed Leukemia clinical trials

View clinical trials related to Relapsed Leukemia.

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NCT ID: NCT05519384 Recruiting - Refractory Leukemia Clinical Trials

Safety and Preliminary Efficacy of JK500 Cell Injection in Relapsed/Refractory Pediatric Acute Myeloid Leukemia

Start date: September 14, 2022
Phase: Early Phase 1
Study type: Interventional

This study is a prospective, single-center, single-arm exploratory clinical study, aiming to complete the preliminary clinical observation of 12 children with relapsed/refractory acute myeloid leukemia treated with JK500 cell injection to evaluate the safety of clinical infusion and the initial efficacy of JK500 cell injection in the treatment of children with relapsed/refractory acute myeloid leukemia.

NCT ID: NCT05495035 Recruiting - Refractory Leukemia Clinical Trials

Study for Safety and Efficacy of Olverembatinib Combined With APG-2575 in Children With Relapsed/Refractory Ph + ALL

Start date: September 1, 2022
Phase: Phase 1
Study type: Interventional

This is an open-label, multicenter, phase 1b study, which is designed to explore the safety, efficacy and PK of olverembatinib, a third-generation tyrosine kinase inhibitor (TKI) marketed in China, in combination with APG-2575 in treating R/R Ph+ALL children, and to preliminarily establish the recommended dose of olverembatinib and APG-2575 for children based on the above results.

NCT ID: NCT05321940 Withdrawn - Clinical trials for Acute Lymphoblastic Leukemia

Safety Trial of STING-dependent Activators and Stimulated Dendritic Cells for Aggressive Relapsed/Refractory Leukemias

Start date: November 30, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this research is to investigate whether the combination of STING-dependent Adjuvants (STAVs) and dendritic cell (DC) vaccine therapies will increase the body's ability to fight aggressive relapsed or refractory leukemias.

NCT ID: NCT02512926 Completed - Clinical trials for Refractory Solid Tumors

Carfilzomib in Combination With Cyclophosphamide and Etoposide for Children

POE14-01
Start date: February 16, 2016
Phase: Phase 1
Study type: Interventional

This study evaluates the use of carfilzomib in combination with cyclophosphamide and etoposide for children with relapsed/refractory solid tumors or leukemia. The medications cyclophosphamide and etoposide are standard drugs often used together for the treatment of cancer in children with solid tumors or leukemia. Carfilzomib is FDA (Food and Drug Administration) approved in the United States for adults with multiple myeloma (a type of cancer). However, this drug is not approved to treat children with relapsed/refractory solid tumors or leukemia. With this research, we plan to determine the DLTs and MTD of Carfilzomib given in combination with cyclophosphamide and etoposide in pediatric patients with relapsed/refractory leukemias and solid tumors.

NCT ID: NCT00923468 Completed - Clinical trials for Relapsed Solid Tumors

Pharmacokinetic Studies Participation Survey

Start date: September 23, 2008
Phase: N/A
Study type: Observational

Background: - A pharmacokinetic (PK) study of a new drug involves taking several blood samples over a period of time from study participants to determine how the body handles the substance. These studies provide critical information about new drugs. - Often, patients or parents of children in drug studies choose not to participate in optional PK studies that are part of the study protocol. - A better understanding of why patients or families do or do not agree to participate in PK studies may help researchers make it easier for people to participate in them. Objectives: - To learn why some people do or do not agree to participate in PK blood sampling studies. Eligibility: - Patients 18 years of age and older and parents or guardians of children who are participating in a study of a drug that includes the option of participating in PK sampling. Design: - Participants fill out a 2-page survey asking about why they did or did not participate in the study's PK sampling.

NCT ID: NCT00315705 Completed - Clinical trials for Acute Lymphoblastic Leukemia

A Study of Clofarabine in Combination With Etoposide and Cyclophosphamide in Children With Acute Leukemias.

Start date: March 2006
Phase: Phase 1/Phase 2
Study type: Interventional

Clofarabine (injection) is approved by the Food and Drug Administration (FDA) for the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia (ALL) who have had at least 2 prior treatment regimens. This use is based on the induction of complete responses. Randomized trials demonstrating increased survival or other clinical benefit have not been conducted. The purpose of the phase 1 portion of this study was to determine if clofarabine added to a combination of etoposide and cyclophosphamide is safe in children with relapsed or refractory acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML). The purpose of the phase 2 portion of the study was to measure the effectiveness of the combination therapy in children with ALL.