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Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma

Refractory Follicular Lymphoma Clinical Trial

Official title:
Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma

Clinical Trial Summary

This is a phase I/II study in which patients will be enrolled in a standard 3+3 design. Once the maximum tolerated dose (MTD) is determined amongst patients with relapsed or refractory grade 1-3a follicular lymphoma, there will be a 17-patient phase II study.

Clinical Trial Description

In vitro studies of ibrutinib and venetoclax have noted significant cytotoxicity and synergy in mantle cell lymphoma and chronic lymphocytic leukemia cell lines.Data have demonstrated synergy between the two agents in various other B-cell Non-Hodgkin Lymphoma (NHL) cell lines. The investigators theorize that the combination of ibrutinib and venetoclax will provide dual, yet unique, targeted inhibition for patients with follicular lymphoma, resulting in both significant efficacy and less nonspecific toxicity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02956382
Study type Interventional
Source Georgetown University
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date March 1, 2017
Completion date November 2024
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