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Precision Medicine for Every Child With Cancer — ZERO2  

Childhood Cancer Clinical Trial

Official title:
Precision Medicine for Every Child With Cancer

Clinical Trial Summary

To improve outcomes for childhood cancer patients through the implementation of precision medicine.

Clinical Trial Description

Through the pilot TARGET and national PRISM trials the feasibility and benefits of using comprehensive molecular profiling and preclinical drug testing in real time for high-risk (HR) patients has been demonstrated. However, the role of precision medicine, especially in facilitating diagnosis and risk stratification in non-HR childhood cancers has not been studied. Integrative tumor-germline whole genome sequencing (WGS) analysis has the potential to advance our understanding of cancer predisposition. In this study, the ZERO platform will be extended to all children with cancer in Australia and New Zealand, evaluating the benefits of precision medicine in different childhood cancer types and risk groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05504772
Study type Observational
Source Australian & New Zealand Children's Haematology/Oncology Group
Contact National Study Coordinator
Phone +61 2 9382 3102
Email SCHN-ZERO2@health.nsw.gov.au
Status Recruiting
Phase
Start date December 16, 2022
Completion date July 2030
View Details
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