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Relapsed Cancer clinical trials

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NCT ID: NCT04310345 Active, not recruiting - Advanced Cancer Clinical Trials

Impact of Human-Animal Interactions on Children With Life-Threatening Conditions and Their Parents

Start date: March 31, 2021
Phase: N/A
Study type: Interventional

This study will evaluate the effects of human-animal interaction on reducing anxiety, depression, worry, and pain and enhancing quality of life in children ages 8-17 years old with a life threatening cancer and their parent caregivers.

NCT ID: NCT03445858 Active, not recruiting - Refractory Cancer Clinical Trials

Pembrolizumab in Combination With Decitabine and Hypofractionated Index Lesion Radiation in Pediatrics and Young Adults

Start date: February 12, 2018
Phase: Early Phase 1
Study type: Interventional

This pilot study is designed to assess the safety, tolerability, and preliminary anti-tumor activity of the combination of pembrolizumab, decitabine and fixed-dose hypofractionated index site radiotherapy in pediatric and young adult patients with relapsed, refractory or progressive non-primary CNS solid tumors and lymphomas. Primary Objectives - To determine the feasibility of administering pembrolizumab in combination with decitabine and hypofractionated index lesion radiation - To identify the treatment related toxicity and tolerability of the combination of decitabine and pembrolizumab with hypofractionated index lesion radiation Secondary Objective To preliminarily define the anti-tumor efficacy of the combination of pembrolizumab, decitabine and hypofractionated index lesion radiation in patients with relapsed, refractory, or progressive non-CNS solid tumors and lymphomas using overall response rate (CR + PR) by irRECIST after 2 cycles of therapy. Exploratory Objectives To profile the kinetics of the immune response and to correlate with promotor methylation changes, nuclear imaging, stool microbiota diversity, and tumor associated antigen immune responses.

NCT ID: NCT03336931 Active, not recruiting - Childhood Cancer Clinical Trials

PRecISion Medicine for Children With Cancer

PRISM
Start date: September 5, 2017
Phase:
Study type: Observational

This is a multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for children and adolescents with high-risk cancer.

NCT ID: NCT03187288 Active, not recruiting - Clinical trials for Acute Myeloid Leukemia

Study of CFI-400945 Fumarate in Patients With Relapsed or Refractory AML or MDS

Start date: May 25, 2018
Phase: Phase 1
Study type: Interventional

This is a phase 1 study of investigational drug CFI-400945 in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic syndrome. The purpose of this phase 1 study is to see how safe and tolerable the study drug is and to determine the best dose (maximum tolerated dose or recommended phase 2 dose) that can be given in this patient population.