Rehabilitation Clinical Trial
Official title:
Effects of Comprehensive Pulmonary Rehabilitation Programs (CPRP) on Patients Undergoing Lung Resection: a Randomized Controlled Trial
The aim of this project is to investigate the effectiveness of implementing a Comprehensive Pulmonary Rehabilitation Program (CPRP) in patients undergoing lung resection surgery. The CPRP encompasses a training regimen combining aerobic exercise, resistance exercises, breathing exercises, and home activities, specifically tailored for patients with limited exercise capacity and impaired lung function. The study seeks to understand the physiological and biological effects of the CPRP in this patient population.
Background: Elderly patients with compromised lung function or poor health conditions undergoing lung resection surgery face an increased risk of postoperative pulmonary complications. Pulmonary rehabilitation programs play a crucial role in enhancing recovery after surgery, having been shown to reduce postoperative pulmonary complications and enhance patients' pre- and post-operative exercise capacity, functional performance, and quality of life. However, due to the heterogeneity of interventions in pulmonary rehabilitation programs, the optimal timing, methods, or duration of exercise training for lung resection patients remain unclear. Additionally, there is a lack of comprehensive research on the changes and impacts of biomarkers in the blood of lung resection patients following intervention with pulmonary rehabilitation programs. Objectives: This study aims to investigate the physiological and biological effects of a comprehensive pulmonary rehabilitation program in lung resection surgery patients with limited exercise capacity and impaired lung function. Research Methods: This study adopts an open label, randomized, parallel design, intending to recruit 96 lung resection surgery participants divided into a control group receiving standard care and an experimental group receiving the comprehensive pulmonary rehabilitation programs. The intervention period spans 1-2 weeks pre-surgery, during hospitalization, and 3-6 weeks post-discharge. Participants will undergo four assessments at randomization (baseline, T0), one day pre-surgery (T1), the day of discharge post-surgery (T2), and at trial completion (T3). The primary endpoint is the six-minute walk test. Secondary endpoints include lung function, lung expansion volume, respiratory muscle strength, incidence of postoperative complications and pulmonary complications, chest tube duration, length of hospital stay, quality of life (EORTC QLQ-C30), and pain. Exploratory endpoints involve inflammation-related and immune-related biomarkers. Expected Impact: This study will provide valuable insights into the physiological and biological effects of a comprehensive pulmonary rehabilitation programs for lung resection surgery patients. Results may contribute to improving patient outcomes and advancing academic understanding and clinical guidelines in this field. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04458480 -
Effect of Fast Inpatient Rehabilitation After TKA
|
||
| Recruiting |
NCT06238596 -
Rehabilitation Intervention to Prevent Adverse Events Related to Androgen-deprivation Therapy (ADT) in Patients With Metastatic Prostate Cancer (PCa): a Single Arm Feasibility Study (ReCaP Study)
|
N/A | |
| Recruiting |
NCT05547152 -
Evaluation of the Effectiveness of Virtual Reality Self-rehabilitation in the Treatment of Facial Paralysis and Synkinesis
|
N/A | |
| Active, not recruiting |
NCT05520528 -
Impact of Group Participation on Adults With Aphasia
|
N/A | |
| Completed |
NCT03661944 -
Functional Performance Assessments in Overhead Athletes With Shoulder Injury
|
||
| Completed |
NCT05875480 -
The Effectiveness of Telerehabilitation After Arthroscopic Meniscus Repair
|
N/A | |
| Not yet recruiting |
NCT05854056 -
Tibial Tubercle Distalisation and Accelerated Rehabilitation
|
N/A | |
| Not yet recruiting |
NCT05177380 -
Efficacy of a Personalized Rehabilitation Program of Facial Involvement in Systemic Sclerosis
|
N/A | |
| Not yet recruiting |
NCT04419753 -
The Role of Attention Focus Walking Training in Older Adults.
|
N/A | |
| Not yet recruiting |
NCT03628495 -
Effectiveness of a Combined Pressure and Silicone Intervention for Hypertrophic Scar Treatment
|
N/A | |
| Completed |
NCT02413996 -
Effects of Virtual Reality Rehabilitation in Patients With Total Knee Arthroplasty
|
N/A | |
| Completed |
NCT01205542 -
Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Shoulder Function
|
N/A | |
| Completed |
NCT02644096 -
Rehabilitation of Patients After THR - Based on Patients´Selfrated Health
|
Phase 1 | |
| Completed |
NCT03582371 -
Aqua Stand-Up Paddle Balance Effect in Parkinson's Disease (AquaSUP PARK)
|
N/A | |
| Completed |
NCT05655039 -
The Effect of Pre-rehabilitation and Rehabilitation Period on Functional Status in Inpatient Stroke Patients
|
||
| Completed |
NCT04502654 -
Rehabilitation for Thoracoscopic Lobectomy
|
||
| Completed |
NCT06206018 -
Patient-Reported Outcome Measures in Lower Extremity Rehabilitation Program PROM_R: Impact on Health Care
|
N/A | |
| Completed |
NCT03386604 -
Physical Capacity of Patients With Chronic Obstructive Pulmonary Disease With and Without Supplementation of Whey
|
N/A | |
| Recruiting |
NCT05619666 -
Acute Rehabilitation in Patients With COVID-19 Pneumonia
|
N/A | |
| Completed |
NCT06251791 -
Inspiratory Muscle Training and Expiratory Muscle Thickness
|
N/A |