Clinical Trial Details
— Status: Active, not recruiting
Administrative data
| NCT number |
NCT05217771 |
| Other study ID # |
8976 |
| Secondary ID |
|
| Status |
Active, not recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
November 10, 2021 |
| Est. completion date |
November 20, 2022 |
Study information
| Verified date |
January 2022 |
| Source |
October 6 University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
The Coronavirus Disease 2019 (COVID-19) is a highly transmittable and pathogenic viral
infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2), which
emerged in Wuhan, China in December 2019 and its spread around the world has been rapid
(Rathi et al., 2021; Vakili et al., 2021). COVID-19 impacts on economy, society, education ,
neurological, psychiatric and psychosocial impairments , increasing the burden of disease and
disability throughout the world have been studied by several authors (Phillips et al., 2020;
Pragholapati, 2020).
COVID-19 may lead to greater risks of long-term scarring, permanently lower economic
activity, a significant increase in the prevalence of chronic illness, social distancing,
isolation, changes in teaching and learning strategies to decrease of number of days of
education, the number of social contacts each day is limited (Minister & Majesty, 2020;
Almomani et al., 2021) .
Description:
The Coronavirus Disease 2019 (COVID-19) is a highly transmittable and pathogenic viral
infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2), which
emerged in Wuhan, China in December 2019 and its spread around the world has been rapid
(Rathi et al., 2021; Vakili et al., 2021). COVID-19 impacts on economy, society, education ,
neurological, psychiatric and psychosocial impairments , increasing the burden of disease and
disability throughout the world have been studied by several authors (Phillips et al., 2020;
Pragholapati, 2020).
COVID-19 may lead to greater risks of long-term scarring, permanently lower economic
activity, a significant increase in the prevalence of chronic illness, social distancing,
isolation, changes in teaching and learning strategies to decrease of number of days of
education, the number of social contacts each day is limited (Almomani et al., 2021; Minister
& Majesty, 2020) .
Thus, multi-organ injuries are observed in COVID-19, such as acute respiratory distress
syndrome, acute myocardial injury, acute kidney injury, and acute liver injury. Survivors of
severe COVID-19 are also found to be with multi-organ impairments after discharge (Dennis et
al., 2021)
Clinical presentation of COVID- I9 ranges from absence of symptoms to severe pneumonia while
fever, dry cough and fatigue, dyspnea, myalgia, arthralgia, distress, anxiety, and depression
are common symptoms. The uncommon symptoms include sputum production, headache, hemoptysis,
nausea, vomiting and diarrhea among COVID-19 patients (Feng et al., 2020).
Different Phases of COVID-19 defining acute COVID-19 or transition phase: (signs and symptoms
of COVID-19 for up to 4 weeks), Acute post COVID symptoms: (signs and symptoms of COVID-19
from 4 to 12 weeks), and long post-COVID-19 syndrome (signs and symptoms that develop during
or after an infection consistent with COVID-19, continue for more than 12 weeks up to 24
weeks and are not explained by an alternative diagnosis). persistent post COVID symptoms:
symptoms lasting more than 24 weeks (Fernández-de-las-Peñas et al., 2021; Yong, 2021a).
The persisted symptoms of post COVID-19 syndrome are correlated with the severity of illness
during acute phase. The illness severity pattern could be categorized as follow; asymptomatic
infected patients, symptomatic patients isolating at home, symptomatic patients admitted to
hospital, and symptomatic patients requiring ventilatory support in critical care which can
lead to permanent sequelae and even death (Castroa et al., 2021).
Persistent post-COVID syndrome (PPCS) or long COVID is a pathologic entity, which involves
persistent physical, medical, and cognitive sequelae following COVID-19 as symptoms at least
one symptom persists for more than three months after the first symptom onset up to six
months. Patients who were no longer positive for SARS-CoV-2 and discharged from the hospital,
as well as outpatients, can also develop long COVID (Oronsky et al., 2021).
COVID-19 is a multisystem disease, which in certain cases will require full multidisciplinary
team (MDT) rehabilitation required many specialties to enable recovery. The British Society
of Rehabilitation Medicine (BSRM) have recently published a position statement that includes
the rehabilitation care pathways and coordinated networks that will be required following the
COVID-19 pandemic (Barker-Davies et al., 2020).
Rehabilitation may work for treating certain cases of post COVID. There are existing
rehabilitation pathways that assess and manage the rehabilitation needs of patients with
long-term conditions, notably, cardiac, and pulmonary rehabilitation pathways. These services
accommodate patients with multiple comorbidities, including chronic respiratory disease, and
cardiovascular, mental health and metabolic diseases. Reviews have also recommended that
rehabilitation programs be personalized since post COVID manifestation and pathophysiology
may vary in each case (Singh et al., 2020).
High tone power therapy (HiTop) is a new quantum leap in the field of electro therapy without
muscle and nerve stimulation. It is electrotherapy with sinusoidal alternating currents. The
high tone power therapy provides a therapy with medium frequency sine waves. The therapy is
free of direct current (D.C.) components. The amplitude and the frequency are modulated
simultaneously. The higher the frequency, the more energy can be introduced corresponding to
the individual threshold curve of the patient's electro sensitivity (Medizintechnik, 2008).
High Tone power therapy is increase mitochondria in number and size. The differences in
effect relate to two main mechanisms of High Tone power therapy: First, it introduces energy
into the body to increase the cell energy potential, to activate cells, to revitalize the
body, producing a resonance effect that creates an oscillation or vibration in the cells and
tissues. Second, it makes the cell structures oscillate to normalize the metabolism,
scattering the mediators of inflammation, nutrients, and waste substances (Requena et al.,
2005). so that high tone will be treat persisted symptoms of covid-19.
