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Clinical Trial Summary

A Phase 1 first-in-human dose-escalation and dose-expansion study of BMF-219, an oral covalent menin inhibitor, in adult patients with AML, ALL (with KMT2A/ MLL1r, NPM1 mutations), DLBCL, MM, and CLL/SLL.


Clinical Trial Description

A Phase 1 first-in-human dose-escalation and dose-expansion study of BMF-219, an oral covalent menin inhibitor, in adult patients with acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) with mixed lineage leukemia 1-rearranged (KMT2A/ MLL1r), nucleophosmin 1 (NPM1), diffuse large b-cell lymphoma (DLBCL), multiple myeloma (MM), and chronic lymphocytic lymphoma (CLL)/ small lymphocytic lymphoma (SLL). ;


Study Design


Related Conditions & MeSH terms

  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Cancer
  • Chronic Lymphocytic Leukemia
  • Diffuse Large B Cell Lymphoma
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Lymphoma
  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, Non-Hodgkin
  • Multiple Myeloma
  • Myeloma, Plasma-Cell
  • Myelomatosis
  • Neoplasms, Plasma Cell
  • Plasma Cell Myeloma
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Progression
  • Refractory
  • Small Lymphocytic Lymphoma

NCT number NCT05153330
Study type Interventional
Source Biomea Fusion Inc.
Contact Mona Vimal
Phone 1-844-245-0490
Email clinicaltrials@biomeafusion.com
Status Recruiting
Phase Phase 1
Start date January 24, 2022
Completion date March 31, 2025

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