Refractory Multiple Myeloma Clinical Trial
Official title:
Maintenance Therapy With Thalidomide, Dexamethasone and Clarithromycin (Biaxin) Following Autologous/Syngeneic Transplant for Multiple Myeloma
This phase II trial studies the side effects and how well giving thalidomide, dexamethasone, and clarithromycin together works in treating patients with multiple myeloma previously treated with transplant. Biological therapies, such as thalidomide and clarithromycin, may stimulate the immune system in different ways and stop cancer cells from growing. Dexamethasone also works in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving thalidomide together with dexamethasone and clarithromycin after a transplant may be an effective treatment for multiple myeloma
OBJECTIVES:
I. Evaluate the toxicity of the use of Thalidomide/Biaxin (Clarithromycin)/Dexamethasone as
maintenance therapy after autologous/syngeneic transplant.
II. Evaluate the median time to disease progression. III. Evaluate survival.
OUTLINE:
Patients receive thalidomide orally (PO) once daily (QD), dexamethasone PO once weekly, and
clarithromycin PO twice daily (BID). Treatment continues for 1 year in the absence of
disease progression or unacceptable toxicity. Treatment with thalidomide continues in the
absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up periodically.
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