Refractory Glaucoma Clinical Trial
Official title:
Ahmed Valve Glaucoma Implant With Adjunctive Subconjunctival Bevacizumab in Refractory Glaucoma: a Randomized Controlled Clinical Trial
The investigators aim to demonstrate the efficacy and safety of subconjunctival injection of Avastin as an adjunctive therapy for Ahmed valve glaucoma implant in patients with refractory glaucoma.
Several studies have revealed evidences on the substantial role of Vascular endothelial
growth factor-A (VEGF-A) in enhancing neovascularization processes. Some studies have shown
the efficacy of intravitreal Avastin in reducing level of VEGF-A to improve NVG. On the
other hand, recent pathological studies demonstrated that neutralization of VEGF reduced
vascularity and decreased scar formation during wound healing, showing that VEGF strongly
influence scar tissue formation. This may reduce the formation of encapsulated cyst after
glaucoma surgeries and thus might improve the surgical success rate. The effect of
subconjunctival bevacizumab as an adjunctive therapy in filtering glaucoma surgeries has
been recently illustrated.
We aim to demonstrate the efficacy and safety of subconjunctival injection of Avastin as an
adjunctive therapy for Ahmed valve glaucoma implant in patients with refractory glaucoma.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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