Refractive Surgery Clinical Trial
Official title:
Accelerated Versus Standard Corneal Cross Linking in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty: A Long Term Randomized Trial.
WHAT WAS KNOWN
*Standard CXL is the common procedure for treating progressive corneal ectasia. Modifications
of the standard protocol were introduces to reduce its complications especially long exposure
to ultraviolet rays. The Accelerated protocol, while believed to overcome this issue with
comparable outcomes, has not been studied fully in patients with ectasia following corneal
refractive surgery and penetrating keratoplasty.
WHAT THIS PAPER ADDS Accelerated CXL is as safe and effective as the Standard CXL in halting
the progression of ectasia post refractive surgery and penetrating keratoplasty with the
benefit of: reduced ultraviolet exposure, reduced operation time, and reduced patient
discomfort.
Purpose:
The aim of this study is to compare the clinical outcomes of the Standard CXL and the AC CXL
in patients with progressive corneal ectasia post refractive surgery and penetrating
keratoplasty.
Setting:
Menoufia University Hospital, Egypt
Design:
Prospective, randomised comparison.
Methods:
Patients scheduled to receive either Standard CXL (3mW/cm2 for a period of 30 min) or
Accelerated CXL (18mW/cm2 for a period of 5 min).The main outcomes for comparison were the
change in; Maximum-K reading (K-max), manifest refractive spherical equivalent (SE), central
corneal thickness (CCT), and the best corrected distance visual acuity (CDVA).
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