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Clinical Trial Summary

On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.


Clinical Trial Description

Consecutive patients with symptomatic Barrett's esophagus are recruited and receive biopsy for esophageal metaplastic mucosa and gastric mucosa over the antrum and body during endoscopy on enrollment. The biopsy protocol for esophageal metaplastic mucosa is following Seattle protocol. GERD Q score will be conducted on enrollment. Additionally, blood sampling for CYP2C19 genotyping is also conducted on enrollment. The eligible subjects will be treated by 8-week esomeprazole, and are then randomly assigned to receive either maintenance or on-demand esomeprazole therapy (40 mg q.d.) for 40 weeks. The patients were asked to come back every four weeks for the recording of symptom days and PPI tablet consumption numbers. Follow-up endoscopy with biopsy for esophageal and gastric mucosa is performed at the end of the 48th weeks. We will compare the effects of maintenance and on-demand PPI therapy on (1) histological changes of esophageal metaplastic mucosa (2) symptom control (3) tablet consumption number ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04329000
Study type Interventional
Source Kaohsiung Veterans General Hospital.
Contact
Status Completed
Phase N/A
Start date February 2, 2010
Completion date December 8, 2019

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