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Clinical Trial Summary

This study compares patients' acceptability and safety of two established endoscopic methods for treating dysplastic Barrett's esophagus: radiofrequency ablation versus hybrid argon plasma coagulation.


Clinical Trial Description

Both endoscopic radiofrequency ablation (RFA) and argon plasma coagulation (APC) are established treatment modalities for dysplastic Barrett's esophagus. Recently, a modification of the APC method has emerged, which involves a submucosal injection of saline preceding the thermal ablation (hybrid-APC; h-APC). This allows to increase the procedure's safety and presumably reduces the patients' post-procedural discomfort. Although both RFA and h-APC are characterized by high effectiveness in eradicating Barrett's segments, limited data compares the patient-related aspects of the procedures. To fill this knowledge gap, we set out a single-center randomized-controlled trial to compare procedural acceptability, safety, and impact on the quality of life, of the two methods. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05051475
Study type Interventional
Source Centre of Postgraduate Medical Education
Contact Wladyslaw Jannuszewicz, MD
Phone +48 546-23-28
Email wjanuszewicz@cmkp.edu.pl
Status Recruiting
Phase N/A
Start date December 1, 2021
Completion date December 31, 2023

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