Red Blood Cell Disorder Clinical Trial
— GR-ExOfficial title:
Pathophysiological Explorations of Red Blood Cells
GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of erythropoiesis, red blood cells and iron metabolism, and to develop new therapeutic protocols capable of providing added value in terms of innovation.
Status | Recruiting |
Enrollment | 3750 |
Est. completion date | October 15, 2037 |
Est. primary completion date | October 15, 2037 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - To be affected or have a family history of disease bound to the red blood cell, - For adult subjects, have signed an informed consent form, - For minor or major under legal safeguard subjects, the form must be signed by both parents (for minors) or by the legal representative, - Be affiliated to health insurance. Exclusion Criteria: - Being deprived of freedom |
Country | Name | City | State |
---|---|---|---|
France | Hopital Necker - Enfants malades | Paris |
Lead Sponsor | Collaborator |
---|---|
Imagine Institute |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Innovative markers of spleen fonctionality | Retention rate (%) of red blood cells using Microsphiltration compared with non affected subjects | 20 years | |
Primary | Quantification of inflammation in sickle cell disease | Activation rate of circulating mastocytes (%) | 20 years | |
Primary | Markers of post-artesunate hemolysis | Concentration of pitted red blood cells at day 3 | 20 years | |
Primary | Correlation between transfusion yield and the storage of red blood cell bags | Increasing in haemoglobin concentration at 6 hours post transfusion | 20 years | |
Primary | Efficiency of Phosphodiesterase inhibitor on neutrophil adhesion in Sickle cell disease | Proportional change in adhesion rate (%) of neutrophils measured in the peripheral blood before and after treatment with phosphodiesterase inhibitors | 20 years | |
Primary | Quantification of mitochondria removal during erythropoiesis in SDC patients, consequences on the mature RBC | Mitochondria rate and level of ROS in RBC measured by Flow Cytometry | 20 years | |
Primary | Study of iron metabolism in Diamond-Blackfan Anemia patients | Dosage of iron metabolism parameters | 20 years |
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