Intravesical Gentamicin to Prevent Recurrent UTI

Status Not yet recruiting

Clinical Trial Summary

Feasibility assessment of intravesical gentamicin instillation (putting antibiotics directly into the bladder) versus the current standard of care of oral nitrofurantoin prophylaxis (taking a low dose of antibiotics by mouth every day) to prevent recurrent urinary tract infections (UTI)

Clinical Trial Description

The overall goal of this project is to assess the feasibility of a larger trial investigating the use of intravesical gentamicin instillation (putting antibiotics directly into the bladder) versus the current standard of care of oral nitrofurantoin prophylaxis (taking a low dose of antibiotics by mouth every day). Investigators plan to gain patient perspective regarding preferences for study design and assess associations between the treatments with changes in the postmenopausal urinary microbiome (urobiome). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06332781
Study type	Interventional
Source	Women and Infants Hospital of Rhode Island
Contact
Status	Not yet recruiting
Phase	Phase 4
Start date	August 1, 2024
Completion date	July 31, 2025

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See also
Status	Clinical Trial	Phase
Terminated	`NCT04096820` - Uromune in Treating Recurrent Urinary Tract Infections in Women	Phase 2
Completed	`NCT03210038` - Cystoscopy in Females: Is There a Difference Between Rigid and Flex Cystoscopy, and Does it Require Local Anasthesia?	N/A
Completed	`NCT03644966` - Probiotics and Multi-Drug Resistant Urinary Tract Infection	N/A
Recruiting	`NCT06149676` - A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections	Early Phase 1